Drugs
Researchers at Shandong University have found that des-gamma-carboxy prothrombin (DCP) stimulates the growth of human hepatocellular carcinoma (HCC) cells and increases the expression of angiogenic factors, including vascular endothelial growth factor (VEGF), transforming growth factor-alpha (TGF-alpha), and basic fibroblast growth factor (bFGF). The study's lead author, F.J.
Drugs
A new study published in The Journal of Pharmacy and Pharmacology explores the potential of chitosan nanoparticles in cancer treatment, highlighting the development of drug delivery systems that target cancerous lesions in the body. Researchers investigated the use of DNAzyme and siRNA encapsulation into chitosan nanoparticles, discussing the current and
Drugs
Researchers from Karolinska University in Stockholm, Sweden, have investigated the association between ultrarapid drug metabolism and therapeutic failures of antidepressants. According to their study, published in the European Journal of Clinical Pharmacology, the CYP2C19*17 allele is linked to higher levels of CYP2C19 gene transcription and increased metabolism rates of
Drugs
Researchers from Cornell University have conducted a study on the effects of NSC606985, a water-soluble camptothecin analog, in prostate cancer cells. The study indicates that NSC606985 is capable of inducing apoptosis and growth arrest in prostate tumor cells, which may involve an interaction with topoisomerase 1 and an activation of
Drugs
A study in Scotland has demonstrated the safety of a novel multi-targeted growth inhibitor (MTGI), ZK 304709, but found it to be ineffective at high doses. The compound, administered orally to 40 patients with advanced solid malignancies, was well-tolerated up to a dose of 360 mg. However, blood concentrations increased
Drugs
Researchers from the Medical University of South Carolina have made a significant discovery in the treatment of cholestatic liver injury, a condition that can lead to liver failure. The study, published in the Journal of Pharmacology and Experimental Therapeutics, found that a mitochondrial permeability transition inhibitor, NIM811, can effectively reduce
Drugs
Pharmacogenetics, the study of how genetic variations affect the way individuals respond to medications, has emerged as a critical area of research in breast cancer therapy. Recent studies have highlighted the importance of genetic polymorphisms in drug-metabolizing enzymes and transporters in determining the efficacy and toxicity of various chemotherapeutic agents.
Drugs
Researchers from Monash University in Clayton, Australia, have reported the emergence of colistin resistance in multidrug-resistant Gram-negative bacteria, specifically Klebsiella pneumoniae. The study, published in the Journal of Antimicrobial Chemotherapy, examined the in vitro pharmacodynamic properties of colistin against 21 multidrug-resistant clinical isolates of K. pneumoniae from 16 different clinical
Drugs
Researchers at the Mayo Clinic have made a new discovery that could be crucial for treating some women with breast cancer. The study found that women with an inherited deficiency in the CYP2D6 gene have a nearly fourfold higher risk of early breast cancer recurrence compared to women who do
Drugs
Gene therapy is a growing field of research aimed at using genes to treat or cure diseases. Recent studies from Tokyo, Japan, have presented a promising approach to cancer gene therapy using folate-linked lipid-based nanoparticles for synthetic siRNA delivery in KB tumor xenografts. According to researchers from Hoshi University, these
Drugs
Recent research, led by A. Broniscer and colleagues from the St. Jude Children's Research Hospital, has shed light on the effectiveness of a treatment combination for brain cancer in children. The study, published in Clinical Cancer Research, aimed to estimate the maximum tolerated dose (MTD) and dose-limiting toxicity
Drugs
In a groundbreaking study published in Toxicology and Applied Pharmacology, researchers from the University of Coimbra in Portugal have revealed a crucial link between hyperglycemia and mitochondrial function in hepatocytes (liver cells). The team found that high glucose levels induce a significant increase in reactive oxygen species (ROS) generation, leading
