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Research published in the May 15, 2005, issue of Cancer Research demonstrated that a monoclonal antibody, Tarvacin, in combination with docetaxel significantly inhibited human breast cancer growth in mouse models. The study found that the combination therapy resulted in a 93% inhibition of tumor growth, compared to 50% and 70%
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Scientists in Japan have identified the angiotensin II type 1 receptor as a potential target for ovarian cancer therapy. According to a study published in Clinical Cancer Research, this receptor is expressed in a significant proportion of invasive ovarian adenocarcinomas and is involved in tumor progression and angiogenesis. The researchers
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Cytogen, a biopharmaceutical company, and Dowpharma, a business unit of The Dow Chemical Co., have entered into a collaboration to create a targeted oncology product designed to treat prostate and other cancers. Under the agreement, Dowpharma's proprietary MeO-DOTA bifunctional chelant technology will be used to radiolabel Cytogen'
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Researchers in Japan, Switzerland, and Germany have published groundbreaking studies on cancer vaccines, offering new hope for cancer patients. The studies focus on developing potent immunogenic general cancer vaccines that target survivin, an inhibitor of apoptosis proteins. One study found that a HLA-A24-restricted antigenic peptide, survivin-2B80-88, recognized by CD8+ CTL,
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Combining GVAX cancer vaccines with anti-angiogenesis agents that block vascular endothelial growth factor (VEGF) demonstrates significant antitumor activity in preclinical tumor models. This combination treatment shows promise in various types of cancer, including melanoma, prostate cancer, lung cancer, pancreatic cancer, leukemia, and myeloma. Preclinical studies presented at the American Association
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Scientists at Cell Genesys, Inc., have developed a proprietary gene expression technology that enables the production of full-length monoclonal antibodies at commercially relevant levels from a single production cell line. This innovative technology, which uses adeno-associated viral (AAV) or other viral-based genetic engineering, can significantly shorten the time required to
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Researchers at the University of Minnesota investigated the impact of arsenic trioxide on primary cultures of endothelial cells and tumor tissue under varying pH and pO[subscript]2 environments. The study aimed to determine whether combined arsenic trioxide and radiation therapy could synergistically increase the effectiveness of cancer treatment. The
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Researchers at the University of Pittsburgh have identified protein phosphatases, specifically dual-specificity phosphatases (DSPases), as potential therapeutic targets for the treatment of cancer and Alzheimer's disease. The study, published in the Annual Review of Pharmacology and Toxicology, highlights the critical roles of DSPases in multiple signaling pathways and
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Representatives from major research institutions and pharmaceutical companies worldwide showcased the critical role of Transgenomic's products and services in their groundbreaking research presentations at the American Association of Cancer Research annual meeting in Anaheim. Researchers utilized Transgenomic's tools for various applications, including mutational analysis, methylation status,
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Patients with chronic hepatitis C who are naive to interferon-alpha treatments showed significant antiviral activity and were well-tolerated to Albuferon, a new treatment option in development by Human Genome Sciences, Inc. (HGSI). The phase II clinical trial, presented at the 40th Annual Meeting of the European Association for the Study
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Eli Lilly and Co. has taken a substantial step towards advancing cancer research by committing $12.5 million to the Damon Runyon Cancer Research Foundation. This significant contribution aims to accelerate the pace and progress of cancer research in the United States. According to an American Cancer Society report, cancer
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Scientists in the United States and People's Republic of China have made significant advancements in cancer therapy by exploring novel angiogenesis inhibitors, compounds that can halt the growth of new blood vessels that feed tumors, thereby preventing cancer progression and metastasis. Recent studies have shed light on the
