Gene therapy
Scientists at Instituto Superior Tecnico have made significant strides in cancer gene therapy by developing novel dendrimers that demonstrate intrinsic anticancer activity. According to the research, these dendrimers, specifically PUREG4-OEI48 and PUREG4-OCEI24, disrupt cell membrane integrity, interact with mitochondria, and induce cell death by promoting apoptosis. The findings indicate that
Gene therapy
Researchers at Ain Shams University have made groundbreaking findings in the treatment of Ehrlich ascites carcinoma (EAC), a rapidly growing tumor model, by developing targeted liposomal nano-therapy combining anthocyanin and cisplatin. This innovative approach not only reduces systemic toxicity but also enhances anticancer efficacy against EAC, demonstrating a promising future
Gene therapy
New research has shed light on the shortcomings of traditional chemotherapy and the potential of targeted drug delivery systems (DDS) for enhanced cancer treatment. According to a study published in the Journal of Drug Delivery Science and Technology, cancer remains a major global health concern, necessitating the development of novel
Gene therapy
Researchers from the University of Science and Technology China have made a significant discovery in the field of gene therapy, revealing that neuronal pentraxin 1 (NPTX1) plays a key role in the development of post-stroke atherosclerosis by inducing endothelial cell senescence. This study, published in International Immunopharmacology, suggests that NPTX1
Gene therapy
Researchers from the Department of Medicine at Baylor College of Medicine have made a significant discovery in the field of gene therapy. By studying the role of BMPER (bone morphogenetic protein-binding endothelial regulator) in pulmonary arterial hypertension, they have identified a potential therapeutic strategy for mitigating the disease. According to
Gene therapy
Gene therapy for Severe Combined Immunodeficiency (SCID), a rare inherited immune disorder, has faced significant challenges, particularly for RAG-deficient SCID. However, a recent patent filing by Laura Garcia-Perez, Arjan C. Lankester, Karin Pike-Overzet, Frank J. T. Staal, and Marja C. J. A. Van Eggermond from the Academy Hospital Leiden (H.
Gene therapy
During World Blindness Awareness Month, Opus Genetics, a clinical-stage biopharmaceutical company, was highlighted on Good Morning America for its pioneering work in developing gene therapies for inherited retinal diseases. The feature story centered around Lindsey Rambo, the second participant in Opus Genetics' ongoing Phase 1/2 trial of gene
Gene therapy
A recent study by researchers at Nantong University has shed light on the crucial role of vascular endothelial dysfunction in atherosclerosis-induced erectile dysfunction (AED). The research, published in the journal Translational Andrology and Urology, found that the shared pathogenic drivers of atherosclerosis and AED contribute to a bidirectional relationship, with
Gene therapy
Research conducted at Anhui University of Science and Technology in Huainan, People's Republic of China, has led to a groundbreaking discovery in the field of biotechnology and gene therapy. The study, published in Signal Transduction and Targeted Therapy, identified peroxiredoxin 4 (PRDX4) as a critical regulator in the
Gene therapy
A new study on gene therapy, conducted by researchers at Southeast University in Nanjing, People's Republic of China, has made significant progress in developing nucleic acid amplification-based surface-enhanced Raman scattering (SERS) methods for in vitro and in vivo biosensing. The research, supported by the Frontier Technologies R &
Cancer
Researchers from Bezmialem Vakif University have made significant advancements in cancer gene therapy, discovering a novel delivery system that uses phototherapies to target and treat melanoma. The study, published in the European Polymer Journal, has demonstrated the potential of multifunctional glycopeptide-based nanoplexes to selectively deliver therapeutics to cancer cells. Key
Genetic research
A comprehensive study conducted by researchers from the Third Affiliated Hospital of Chongqing Medical University has shed light on the global research landscape of hepatic stellate cells (HSCs) in hepatoma. The study analyzed 510 publications from 2009 to 2023, revealing significant growth in annual publications since 2018, with China, the
