Cancer
A team of researchers from Guizhou University has designed and synthesized a novel nanoplatform that combines photodynamic therapy (PDT) with photothermal therapy (PTT) to overcome cancer treatment resistance in hypoxic tumors. The study, published in the journal Lasers in Medical Science, demonstrates the efficacy of the PEGylated liposomes in enhancing
Genetic research
Researchers at the University of Miami have found that long-acting extracellular vesicle-based biologics have potential in treating osteoarthritis, a chronic degenerative joint disease characterized by low-grade inflammation, cartilage breakdown, and persistent pain. According to a new study, these biologics have shown promise in modifying disease progression and improving patient outcomes.
Genetic research
Cancer gene therapy has been an area of significant research, with companies like ViraTherapeutics GmbH working towards developing new treatments. According to a recent study, researchers at ViraTherapeutics GmbH have published a paper detailing the importance of maintaining viral integrity during the purification process of replication-competent enveloped virus particles. These
Genetic research
Scientists at Tufts University have made significant progress in developing a gene therapy that targets cardiovascular disease (CVD), one of the leading causes of death globally. By editing the gene responsible for producing a protein that contributes to high levels of blood lipids, researchers were able to achieve durable reductions
Genetic research
Researchers at Shanghai Jiao Tong University School of Medicine have made a significant breakthrough in the field of gene therapy. According to a new report, the team has successfully investigated the immunotherapeutic effects of exosomes derived from leukemia cells with high expression of B7 molecules in tumor-bearing mice. The study&
Cancer
Researchers from the Kermanshah University of Medical Sciences have made a significant discovery in cancer gene therapy, addressing a major challenge in delivering oligonucleotides to the brain, where neurodegenerative diseases occur. The team developed a nanoliposome-based delivery system, dubbed DNZ-NLP, which can effectively transport DNAzymes across the blood-brain barrier. This
Cancer
Researchers at Nanjing Normal University have made a significant breakthrough in cancer gene therapy, developing nitric oxide-responsive degradable drug-loaded liposomal nanomotors that can selectively target and penetrate tumor tissues, providing a promising candidate material for cancer treatment drug delivery systems. The nanomotors, designed to respond to nitric oxide degradation, have
Cancer
A new research report from the Inha University College of Medicine in South Korea discusses the recent advancements in delivery systems for transcription factors (TFs), which have opened new therapeutic opportunities in regenerative medicine, cancer therapy, and genetic disorders. The study highlights the challenges faced by effective TF delivery, including
Genetic research
Preeclampsia is a life-threatening condition that affects human pregnancy, causing maternal and neonatal morbidity and mortality. Researchers at Tongji University in Shanghai, China, have discovered a potential therapeutic approach for treating preeclampsia by enhancing trophoblast function. Their study, published in the journal Placenta, found that indole-3-lactic acid (ILA), a metabolite
Genetic research
Intellia Therapeutics' stock plummeted in premarket trading after details emerged of a grade 4 adverse event in its phase 3 trial of the gene therapy nex-z. However, despite the setback, analysts are confident in the treatment's wider safety profile, particularly in its ability to knock down the
Genetic research
Researchers from the Department of Cardiology have made a groundbreaking discovery in the field of gene therapy, identifying a new target for pulmonary arterial hypertension (PAH). According to a recent study published in Journal of Translational Medicine, the team found that knocking down eIF3a, a protein involved in cell differentiation,
Genetic research
New research from the Korea Research Institute of Bioscience and Biotechnology has made a significant breakthrough in gene therapy, developing a novel triple nanocomplex system that enables efficient nuclear gene delivery in microalgae. The system, which integrates cell-penetrating peptides, nuclear localization signal peptides, and plasmid DNA, has shown promising results
