Genetic research
Current study results on Biotechnology - Gene Therapy have been published, revealing a crucial gene responsible for diabetic cardiac dysfunction. The research, conducted by Sun Yat-sen University, found that the gene ACBP plays a significant role in modulating the bidirectional regulation of cardiomyocyte metabolic and structural associations. According to the
Genetic research
MIT engineers have successfully developed a control circuit that can keep expression levels within a target range, making it a significant breakthrough in the field of gene therapy. This innovation has the potential to treat a wide range of diseases by delivering genes that can help repair or replace faulty
Genetic research
A research team supported by the National Institutes of Health (NIH) has developed and safely delivered a personalized gene editing therapy to treat an infant with a life-threatening, incurable genetic disease. The infant, who was diagnosed with the rare condition carbamoyl phosphate synthetase 1 (CPS1) deficiency shortly after birth, has
Genetic research
Researchers from Sun Yat-sen University in Shenzhen, China, have made significant advancements in the development of mRNA-engineered CAR-T cells, a potential game-changer in the treatment of solid tumors. This innovative approach eliminates the risks of insertional mutagenesis and immunogenicity associated with traditional viral vector-based therapies. The study, published in Biomedicines,
Genetic research
Researchers from the University of Tokyo have released new study results on oncolytic virotherapy, highlighting its potential as a revolutionary treatment for cancer. The study, published in the journal Current Issues in Molecular Biology, explores the benefits of oncolytic viruses, which infect and kill cancer cells, triggering an immune response
Genetic research
Scientists at Tokyo University of Pharmacy and Life Sciences have made a significant breakthrough in gene therapy using microfluidic nanobubbles. According to their research, published in Scientific Reports, microfluidic nanobubbles (MF-NBs) can be used for ultrasound imaging and gene delivery, offering a promising approach for practical applications in the field.
Gene therapy
Despite advances in treatment, patients with sickle cell disease (SCD) continue to face severe complications, including increased rates of blood clots, stroke, and other issues that significantly reduce life expectancy and impact quality of life. The introduction of therapies like Endari and Adakveo has helped mitigate some risks, but substantial
Genetic research
Scientists in Scotland have made a groundbreaking discovery in understanding the cellular function of the protein anterior gradient-2 (AGR2). AGR2 plays a crucial role in various biological systems, including goblet cell formation, limb regeneration, and inhibition of p53. Despite its importance, there has been a lack of well-validated binding proteins
Genetic research
Physician assistants (PAs) play a crucial role in primary and secondary cancer prevention, but a new study reveals that they often lack the necessary knowledge and skills to effectively assess and manage cancer in the primary care setting. L.R. Spence and colleagues at Baylor College of Medicine highlight the
Cancer
Renal cysts and clear cell renal cell carcinoma are prone to occur in individuals with VHL tumor suppressor gene inactivation. Research published in the Journal of the American Society of Nephrology posits that VHL plays a crucial role in the formation of primary cilia in kidney epithelium. However, the underlying
Cancer
Researchers at the University of Wisconsin-Madison have identified 17 FMRFamide-related peptides in the pericardial organ of Cancer borealis, a type of crustacean. This discovery was made possible by the development of two immunoaffinity-based methods, immunoprecipitation and immuno-dot blot screening assay, which were used in combination with mass spectrometry to characterize
Biotechnology
Scientists have developed a method to transfer bacterial artificial chromosomes (BACs) as a single copy into the partially deleted Hprt locus of embryonic stem cells, allowing for tissue-specific expression of the BAC transgene. This technology enables studies that require correct interpretation of data depending on developmentally appropriate transgene expression. The
