Biotechnology
Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 Antibodies Inhibit Gene Transfer in the Brain
Researchers from the University States have discovered that circulating antibodies to wild-type adeno-associated virus type 2 (AAV2) can significantly inhibit recombinant AAV2 (rAAV2)-mediated gene transfer in the brain. According to a study published in the Journal of Virology, approximately 80% of the population maintains antibodies to wild-type AAV2, with