Genes
Researchers at Duke University School of Medicine have made significant advancements in gene therapy, utilizing high-potency capsids to enhance skeletal muscle correction in a mouse model of glycogen storage disease type IIIa (GSD IIIa). This groundbreaking research holds promise for the treatment of this debilitating genetic disorder, which affects multiple
Genes
Researchers from the Huazhong University of Science and Technology in Wuhan, People's Republic of China, have made a groundbreaking discovery in the field of cancer gene therapy. The team, led by Yuhe Zhu, has developed a novel gene delivery system that enhances gene transfer efficiency and reduces the
Genes
Researchers from East China Normal University have made a breakthrough in the field of bioinformatics by developing a novel methodology called scPOEM (single-cell meta-Path based Omics EMbedding). This method can jointly project chromatin accessibility peaks and expressed genes into a shared low-dimensional space, enabling the discovery of biologically meaningful peak-gene
Genes
Researchers from Wuhan Textile University, in Wuhan, People's Republic of China, have made significant contributions to the field of biotechnology and bioinformatics by analyzing single-cell RNA sequencing datasets. Their study aimed to uncover dynamic features of cell processes and provide new insights into cell fate determination. The team&
Genes
Researchers at the University of Michigan have discovered significant sex differences in gene expression and regulation in human skeletal muscle. Using bulk and single-nucleus RNA sequencing and single-nucleus ATAC-seq data from 281 skeletal muscle biopsies, the study found that over 2,100 genes showed highly concordant sex-biased expression across different
Genes
Scientists at the Beijing Academy of Agriculture and Forestry Sciences have made significant progress in understanding the role of superoxide dismutase (SOD) enzymes in edible mushrooms, specifically Lentinula edodes. The study revealed the presence of three proteins containing SOD domains in each of the two monokaryotic strains SP3 and SP30
Genes
Researchers from Rhode Island Hospital and Brown University's Medical School have published a groundbreaking study on vector-free, targeted promoter demethylation in vivo, paving the way for novel gene therapy approaches. The study, published in Trends in Biotechnology, demonstrates the potential of using recombinant, gene-targeted epigenetic editor proteins to
Genes
Researchers from Zhejiang University have conducted an in-depth analysis of the small thioesterase (ST) gene family in Arabidopsis, focusing on identifying peroxisomal ST genes. Their study, published in the International Journal of Biological Macromolecules, has provided insights into the role of these proteins in plant peroxisomes and their functional conservation
Genes
Researchers from the Fred Hutchinson Cancer Research Center have made significant strides in gene therapy, developing a novel mobilization regimen for hematopoietic stem cells (HSCs) that has shown remarkable efficiency and reliability in nonhuman primates. The study, published in Molecular Therapy: Methods & Clinical Development, highlights the potential of this
Genes
Research published in Frontiers in Immunology has revealed a promising breakthrough in gene therapy, highlighting the potential of antigen-specific cytotoxic T lymphocyte (ACTL) therapy in overcoming resistance to chemotherapy and targeted therapy in advanced lung cancer patients. The study, led by researchers from the First Affiliated Hospital of Nanjing Medical
Genes
Researchers at Bydgoszcz University of Science and Technology in Poland have discovered that rotating magnetic fields (RMFs) can significantly enhance bacterial cellulose production efficiency. The study, published in the journal Biomacromolecules, found that RMF exposure led to a 28% increase in wet BC yields and an 18% increase in dry
Genes
Investigators at the University of Shanghai for Science and Technology have made a significant breakthrough in the field of biotechnology by identifying a 13 bp segment, termed D3, as a negative cis-acting element in the 5' untranslated region of the alcohol oxidase 1 promoter (P). This discovery has led
