Genetic research
Current research results have highlighted the efficacy of branched polyethylenimine (PEI) derivatives in gene delivery. A study by researchers at the Mashhad University of Medical Sciences found that PEI polymers can be modified to improve transfection efficiency and reduce cytotoxicity in mammalian cells. The study demonstrated that derivatives with 50%
Genetic research
Researchers have discovered that Roux-en-Y gastric bypass surgery (RYGB) regulates the expressions of microRNA-122 (miR-122) in the hypothalamus, heart, and liver, which may modulate the activities of adenosine monophosphate-activated protein kinase (AMPK), the master regulator of metabolism. The study, conducted at Keimyung University in Daegu, South Korea, used microarray analyses
Genetic research
Researchers at Himeji Dokkyo University have conducted a study on the effects of DNA methyltransferase inhibitors (DNMT inhibitors) in treating high-risk myelodysplastic syndromes (MDS) and leukemia. According to the study, DNMT inhibitors such as decitabine (DAC) induce hypomethylation of the promoter region of the cholesterol 25-hydroxylase (CH25H) gene, leading to
Genetic research
Research conducted by the University of Georgia has discovered that overexpression of the IL-13 gene can effectively prevent high-fat diet-induced obesity and insulin resistance in mice. The study aimed to assess the activity of anti-inflammatory cytokine IL-13 in blocking the negative effects of a high-fat diet on body weight, glucose
Genetic research
Current research has shown promising results for a novel method of RNA interference (RNAi) therapy using targeted microbubbles and ultrasound-targeted microbubble destruction (UTMD). This technology has the potential to provide an important therapeutic option for patients with ovarian cancer. By targeting the survivin gene, researchers were able to inhibit cell
Genetic research
Researchers at the University of Bologna have made a groundbreaking discovery regarding the relationship between gene variants and the effectiveness of antidepressant treatments. The study, published in Molecular Diagnosis & Therapy in 2014, investigated the impact of five genetic variants on the response to either antidepressant pharmacological treatment or interpersonal
Genetic research
A new report on stem cell research, published in Cancer Gene Therapy, presents findings on using human adipose-derived mesenchymal stem cells (hAT-MSCs) to deliver therapeutic genes to brainstem gliomas. This approach, developed by researchers at Samsung Biomedical Research Institute, has shown significant therapeutic effects against brainstem gliomas in both in
Genetic research
New research from Shantou University in Guangdong, People's Republic of China, has found that in utero co-exposure to endocrine disrupting compounds such as cadmium (Cd), bisphenol A (BPA), and polychlorinated biphenyls (PCBs) can perturb fetal development. The study, published in Reproductive Toxicology, investigated the effects of co-exposure on
Genetic research
Researchers from the Institute of Biomedical Engineering, Key Lab of Bio-Medical Diagnostics, CAS, have made a groundbreaking discovery in the field of DNA research. They have developed a novel gene expression vector based on an inverted terminal repeat of adeno-associated virus (AAV) genome. This vector, known as AAV-ITR ssDNA minivector,
Genetic research
Researchers at Zhengzhou University have developed a novel silica-polymer composite nano system for tumor-targeted imaging and p53 gene therapy of lung cancer. The system, named MB-NSi-p53-CS ternary complexes, consists of methylene blue-encapsulated amine-terminated silica nanoparticles and chondroitin sulfate. The nano system exhibited effective p53 condensation ability, efficient p53 protection profile,
Genetic research
Cancer researchers at the University of Akron have made a groundbreaking discovery in the field of cancer gene therapy. Carbon nanotubes have been widely used for drug and gene delivery due to their excellent penetrability and encapsulation efficiency. However, concerns over their toxicity have led scientists to explore alternative materials.
Genetic research
A team of researchers from the Chinese Academy of Sciences has conducted a comprehensive genome-wide phylogenetic analysis to investigate the evolutionary relationships of thiamine pyrophosphate (TPP)-dependent enzymes in plants. The study found that these enzymes are present in all domains of life, but their evolutionary dynamics in plants are
