Genetic research
Research conducted by Yonsei University has discovered a key driver gene, SHFM1, in gastric cancer. The study, published in Cellular Signalling, found that SHFM1 is over-expressed in primary gastric tumors and cell lines, and plays a crucial role in the development of gastric cancer. SHFM1 was found to confer cell
Genetic research
A recent study published in Biochimica Et Biophysica Acta-Molecular Basis of Disease has found that gene transfer of interleukin-6 (IL-6) can effectively reverse obesity-induced fatty liver and insulin resistance in mice. The study, conducted by researchers at the University of Georgia, used a hydrodynamic gene delivery method to introduce the
Genetic research
A recent study published in Diabetes-Metabolism Research and Reviews investigated the frequencies of type 1 diabetes-associated gene polymorphisms and their associations with various diabetes-associated autoantibodies in Egyptian children. The research discovered that most children with diabetes were positive for the HLA(DR3)-DQA1*05-DQB1*02 (DR3-DQ2) haplotype, compared to controls.
Genetic research
Researchers from the University of Georgia have discovered that hydrodynamic delivery of the interleukin 15 (Il-15) gene can effectively prevent diet-induced obesity and obesity-associated complications in mice. The study found that Il-15 gene transfer resulted in multiple beneficial effects, including blockade of weight gain, alleviation of fatty liver, and improvement
Genetic research
Researchers from Xuzhou Medical College in the People's Republic of China have successfully constructed a conditionally replicating adenovirus pPE3-SEA that expresses the staphylococcal enterotoxin A (SEA) gene. This adenovirus vector can be used for experimental studies of tumor-targeted therapies. The study aimed to evaluate the construction and characterization
Genetic research
Gastric cancer, a leading cause of cancer deaths worldwide, has been a focus of research in recent years. A recent study conducted in central China investigated the association between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene polymorphisms and gastric cancer in the Chinese Han population. The study, published in Pharmaceutical
Genetic research
A study published in Molecular Cell has shed light on the crucial role of DNA methylation in plant and vertebrate development, genome stability, and gene regulation. Researchers from China Agricultural University discovered that the Methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. This
Genetic research
Research conducted at the University of Alberta investigated the link between melanoma antigen (MAGE) gene expression and cancer outcomes. The study utilized transcriptomic and survival data from 26 cancer studies through the cBio Cancer Genomics Portal to examine the dysregulation of 34 MAGE genes in cancer. The findings revealed that
Genetic research
MicroRNAs (miRNAs), a type of non-coding regulatory RNA, play a crucial role in various biological processes, including gene expression and disease pathophysiology. Researchers at the University of Chicago investigated the impact of miRNAs on cellular proliferation and found a substantial enrichment for miRNAs that can be used as molecular targets
Genetic research
Researchers at the University of Pennsylvania have successfully developed a method to enhance the immune system's performance through ex vivo gene modification of T cells. This novel approach allows for the redirection of native specificity to target tumor antigens, combining the benefits of antibody therapy, cellular therapy, and
Genetic research
Researchers at the University of Mississippi have developed a novel statistical method that can accurately detect cancer genes from microarray data, potentially revolutionizing cancer treatment and gene therapy. The new method, which does not require stringent assumptions, can identify differentially expressed genes and build a prediction model for genetic profiling
Genetic research
Combining electroporation with chemotherapy and interleukin 12 (IL-12) plasmid DNA has been shown to be a highly effective treatment strategy for various types of spontaneous cancers, including large, refractory, and multiple tumor burdens. This approach, known as electro-chemo-gene therapy (ECGT), has been demonstrated to induce a strong anti-tumor immune response
