University of California
Research on cytometry has led to a discovery that the human c2orf40 gene encodes a tumor suppressor gene called esophageal cancer-related gene-4 (ECRG4), which interacts with the innate immunity receptor complex. According to a study published in Inflammation Research, ECRG4 has pro- and anti-inflammatory activities that depend on cell surface
Genetic research
Researchers have made a significant discovery in the fight against gastric cancer, a leading cause of mortality worldwide. According to a recent study published in Drug Design, Development and Therapy, mesenchymal stem cells (MSCs) have shown great potential in delivering gene therapy for gastric cancer treatment. The study, conducted by
Genetic research
Research from Chiba University, Japan, has made significant strides in understanding the molecular mechanisms underlying bladder cancer oncogenesis and metastasis. According to a recent study published in the International Journal of Oncology, the tumor-suppressive miR-23b/27b cluster plays a crucial role in regulating receptor tyrosine kinase genes, such as EGFR
Genetic research
Stem cell research has made significant progress in recent years, but effective gene delivery systems remain a challenge. A new study from Sun Yat Sen University in Guangdong, People's Republic of China, has developed a nonviral vector, lipopolysaccharide-amine nanopolymersomes (NPs), that shows high in vitro transfection efficiency and
Genetic research
Researchers from Harbin Medical University conducted a study to investigate the relationship between genetic polymorphisms and mRNA expression levels of certain genes and the chemosensitivity of non-small-cell lung cancer cells to gemcitabine and cisplatin. The study used a panel of 17 non-small-cell lung cancer cell lines and found significant correlations
Genetic research
Researchers have investigated the relationship between the renin-angiotensin-aldosterone system (RAAS) and the risk of renal cell cancer (RCC). According to a study, polymorphisms in RAAS genes, specifically in AGT, AGTR1, and ACE, were found to be associated with RCC risk. The study, conducted in the Netherlands, used data from the
Genetic research
Research conducted by X.E. Xi and colleagues at the First Affiliated Hospital of Guangxi Medical University in China has explored the relationship between interleukin (IL)-17A and IL-17F gene polymorphisms and the risk of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 155 patients with HBV-related
Genetic research
A groundbreaking case study published in the Anti-Cancer Drugs journal reveals a remarkable recovery in a 68-year-old man with hepatocellular carcinoma. The research, conducted by a team of Chinese scientists, demonstrates the efficacy of combining transarterial infusion with the p53 gene and interleukin-2 in treating multiple lung metastases. This study
Genetic research
A new study has found that gene therapy of limbal cells can improve wound healing and restore stem cell marker patterns in human diabetic corneas. The research, conducted at the State University of New York, examined the effects of treating limbal cells with adenoviruses harboring full-length c-met mRNA or a
Genetic research
A recent in vitro study conducted at Mansoura University in Egypt has shed new light on the effects of environmental pollutants on prostate cancer cells. The study, published in the Biological Trace Element Research journal in 2014, demonstrated the apoptotic effects of arsenic, cadmium, and chromium on non-tumorigenic human prostate
Genetic research
Researchers from the University of Washington have discovered that standard blood collection procedures can rapidly change the transcriptional and posttranscriptional landscapes of hematopoietic cells, leading to biased activation of specific biological pathways. This study highlights the potential confounding effects of technical artifacts in cancer genomics data and emphasizes the need
Scientists
Researchers in London, United Kingdom, have reported promising results in a study on gene therapy for X-linked severe combined immunodeficiency (SCID-X1). The condition is caused by mutations in the common cytokine receptor γ chain, leading to impaired T and natural killer cell function. Ten children with SCID-X1 were treated with
