Scientists
Extensive genomic and gene expression studies have been performed in gliomas, but the epigenetic alterations that characterize different subtypes of gliomas remain largely unknown. Researchers from Paris, France, have analyzed the methylation patterns of 807 genes in a series of 33 low-grade gliomas, 36 glioblastomas, 8 paired initial and recurrent
Universities and colleges
Researchers in Vienna, Austria have discovered that Raf kinases play a crucial role in cancer, with the three mammalian RAF proteins (A, B, and CRAF) being activated by the human oncogene RAS. This leads to tumor-promoting functions, mediated by the MEK/ERK pathway, which is associated with proliferation in various
Universities and colleges
Researchers in Guiyang, People's Republic of China, have discovered that Rac1, a key intracellular signal transducer, is overexpressed in 94 out of 150 primary non-small cell lung cancer tissues, making it a potential target for cancer gene therapy. The study, published in the International Journal of Molecular Medicine,
Scientists
Gene therapy researchers at the University of California, Los Angeles, have made a significant breakthrough in the delivery of genetic material using nanoparticles incorporated into hydrogels. According to a recent study published in the Journal of Controlled Release, the team, led by Y. Lei, developed a novel process called caged
Scientists
Researchers from the University of Pittsburgh have identified a crucial role for the eleven-nineteen lysine-rich leukemia gene (ELL2) in regulating secretory-specific mRNA production in plasma cells. According to the study, published in the Journal of Biological Chemistry, ELL2 is induced sixfold in plasma cells and drives the production of secretory-specific
Scientists
Recent research published in the journal Carcinogenesis investigates the relationship between genetic variations in estrogen-related genes and the risk of prostate cancer. Using data from the Prostate Cancer Prevention Trial (PCPT), the researchers found associations between specific polymorphisms in the CYP19A1 and UGT1A1 genes and the risk of prostate cancer.
Scientists
Scientists have investigated the function of a Mob1-like gene (At5g45550) in Arabidopsis thaliana, a small flowering plant commonly used as a model organism in plant biology research. The results of the study, published in the journal Gene, reveal that the Mob1-like gene plays a vital role in regulating cell expansion
Universities and colleges
Recent research published in Leukemia Research has shed light on the relationship between the TP53 codon 72 polymorphism and the risk or prognosis of Hodgkin and non-Hodgkin lymphoma. A team of researchers from Charles University in Prague, Czech Republic, conducted a study involving 340 non-Hodgkin lymphoma patients, 298 Hodgkin lymphoma
Scientists
Recent research published in the journal Oncogene has identified a novel targeted treatment strategy for cancer using pharmacologic reversal of epigenetic silencing of the anticancer protein BRM. The study, conducted by S. Gramling and colleagues at the University of Florida, found that compounds RH (RH02032) and GK (GK0037) could effectively
Universities and colleges
Recent research by investigators at the University of Tokyo has demonstrated that glutamine plays a significant role in stimulating the gene expression and processing of sterol regulatory element binding proteins (SREBPs) in human hepatoma HepG2 cells. The study found that increasing the amount of glutamine added to the medium promotes
Scientists
A fundamental question in host-pathogen interactions is the timing, localization, and population distribution of virulence gene expression during infection. Researchers from Stanford University School of Medicine used microarray and in situ single cell expression methods to study Vibrio cholerae growth and virulence gene expression during infection of the rabbit ligated
Universities and colleges
Scientists at the University of Colorado have identified the prostate-derived ETS factor (PDEF) as a unique member of the ETS transcription factor family, with a significant role in regulating the expression of prostate-specific antigen and androgen receptor co-regulation. PDEF expression is highly restricted to epithelial cells and has been found
