Genetic research
Investigators at the University of Oxford have made new discoveries regarding the genetic underpinnings of COVID-19 severity and disease risk. By analyzing RNA sequencing data from a cohort of 185 healthy Europeans, researchers identified regulatory variants that influence the expression and splicing of thousands of genes and transcripts in monocytes,
Genetic research
Researchers at Zhengzhou University have developed a novel CRISPR/Cas12a-based colorimetric paper sensor for the rapid detection of antibiotic-resistant genes in bacterial pathogens. According to the study, this paper sensor provides rapid and low-cost detection with femtomolar-level sensitivity, requiring less than 90 minutes of assay time. The sensor's
Genetic research
A team of scientists at the European Molecular Biology Laboratory (EMBL) has made a significant breakthrough in single-cell sequencing technology, creating a highly sensitive tool that can help uncover links between genetic variants and complex diseases. Known as single-cell DNA-RNA-sequencing (SDR-seq), this innovative approach allows researchers to study both DNA
Genetic research
Research conducted by Sinilga Cernuliene and colleagues at the Faculty of Environmental Engineering in Lithuania has shed light on the genetic diversity of black locust stands in the region. The study, published in Applied Biosciences, found that black locust trees in Lithuania are genetically diverse, with an average allele number
Genetic research
A new study published in Microbial Genomics has applied pan-genomics to understand complex transmission of Mycobacterium tuberculosis (MTBC). Researchers from Peking University constructed a pan-genome (MTB_pan) using 307 complete genomes, representing all eight lineages from the National Center for Biotechnology Information (NCBI). The study aimed to evaluate transmission dynamics
Genetic research
Researchers from Universitas Bangka Belitung in Indonesia have conducted a study on the genetic diversity of black pepper plants in the Bangka Belitung Islands Province, a major centre of black pepper production in Indonesia. The study employed SSR markers to determine the genetic diversity and relationships of Bangka landrace black
Genetic research
Researchers from Osaka University have recently conducted a study that provides a comprehensive annotation of the bovine T cell receptor (TRG) locus, which is essential for understanding the unique immunobiology of cattle. This study used advanced sequencing technologies and comparative genomic analysis to identify previously unannotated TRG genes in the
Genetic research
A recent study published in Genome Biology has revealed the distinct roles of genome, methylation, transcription, and translation on protein expression in Arabidopsis thaliana, resolving the Central Dogma's information flow. The study, conducted by researchers at Rothamsted Research, aimed to investigate the impact of intermediate genomic levels on
Genetic research
Plant research has made a significant breakthrough in understanding the role of non-CG DNA methylation in regulating root development and stress responses in Arabidopsis thaliana under cadmium (Cd2+) exposure. The study, conducted by researchers at the University of Calabria, found that non-CG DNA methylation plays a critical role in maintaining
Genetic research
A study published in ACS Omega has shed light on the mechanisms behind the pathogenesis of chronic arthritic condition associated with Chikungunya virus (CHIKV) infection. This acute viral fever, prevalent in tropical regions, can progress into a chronic condition lasting months or even years. Researchers at the International Centre for
Genetic research
A new study conducted by researchers at Ningxia University in the People's Republic of China has shed light on the crucial role of methylation in regulating gene expression, particularly in beef cattle. The study focused on the NR2E1 gene, which is involved in the modulation of gene expression,
Genetic research
India's biomanufacturing sector stands at rank 3 in the Asia-Pacific region and rank 12 globally, with pharma exports expected to cross $30 billion this year. The country's bioeconomy has grown significantly, from $10 billion in 2014 to nearly $170 billion today, and is projected to reach
