Genetic research
The Saudi Food and Drug Authority has approved the first phase 1 clinical study of a locally developed, novel gene therapy using engineered T-cells (CAR T-cells) to treat patients with aggressive lymphoblastic leukemia. The therapy was developed and manufactured locally within a research environment at King Faisal Specialist Hospital and
Genetic research
Researchers at Fujian Agricultural and Forestry University have conducted a comprehensive study on the effects of arbuscular mycorrhizas (AM) fungi on sugarcane growth and nutrient absorption. The study, funded by the Guangxi Science and Technology Major Special Project, employed pot experiments and analyzed the phenotypic traits, rhizosphere soil nutrient contents,
Genetic research
Research from Air Force Medical University in Xi'an, China, has uncovered significant implications for glioma prognosis and immune responses by examining DNA methylation variations within the DNA damage response mechanism. The study, published in the Journal of Translational Medicine, analyzed a range of public and local glioma datasets
Genetic research
Researchers from the JSS Academy of Higher Education and Research in India have employed machine learning algorithms to identify antibiotic-resistant genes and virulence factors in Escherichia coli strains causing sepsis. The study used whole-genome sequencing and bioinformatic tools to analyze 18 sepsis-causing strains and identified various global and emerging multidrug
Genetic research
Researchers at the Slovak Academy of Sciences have made significant progress in developing a novel cell-free gene-directed enzyme prodrug therapy for pancreatic ductal adenocarcinoma (PDAC). This innovative approach leverages conditioned medium from placenta-derived mesenchymal stem cells engineered to express the yeast cytosine deaminase::uracil phosphoribosyltransferase (yCD::UPRT) fusion enzyme. The
Genetic research
Cancer testis antigens (CTAs) can be expressed in tumors but silenced in normal tissue, making them attractive targets for T cell receptor (TCR) gene therapy. However, CTA-specific TCR gene therapy is only applicable for tumors with substantial and homogeneous CTA expression. Researchers at Leiden University Medical Center have found that
Genetic research
Researchers from China Three Gorges University have developed an ultrasound-targeted liposome nanobubbles system that enables the precise delivery of drugs and genes to treat esophageal squamous cell carcinoma (ESCC). The system, which combines chemical immunotherapy and gene therapy, has shown significant promise in suppressing tumor growth and triggering immunogenic cell
Genetic research
Researchers at Sun Yat-sen University in China have made a groundbreaking discovery in the field of gene therapy, identifying a key mechanism driving chronic obstructive pulmonary disease (COPD) and potential therapeutic targets. The study focuses on the role of cigarette smoke (CS) in triggering ferroptosis, a form of cell death,
Genetic research
In a significant breakthrough, researchers from South China University of Technology have made new data available in the field of biotechnology - gene therapy. According to the research, inhalable nucleic acid drug delivery systems have garnered attention as a promising strategy for treating chronic pulmonary diseases, including asthma, COPD, cystic
Genetic research
Researchers at Sartorius BIA Separations d.o.o. in Ajdovscina, Slovenia, have made significant breakthroughs in the development of gene therapy using lipid nanoparticles (LNPs). According to a new report, LNPs have emerged as the most advanced drug delivery system for gene therapies and vaccines due to their ability to
Genetic research
Researchers at the Pediatric University Hospital in Madrid, Spain have reported a significant breakthrough in the treatment of Fanconi anemia, a rare and debilitating genetic disorder that leads to bone marrow failure and an increased risk of cancer. According to a recent study published in Frontiers in Pediatrics, the researchers
Genetic research
A new study on Life Sciences - Microbiology reveals the impact of aquaculture on antimicrobial resistance gene profiles and microbiota in marine and freshwater sediments. The study employed target-enrichment metagenomics and a Resistomap qPCR assay to assess the resistome in sediments associated with active Canadian finfish aquaculture operations. The research
