Genetic research
Researchers from the University of Pisa have made a significant breakthrough in the field of gene therapy by developing linear DNA-chitosan nanoparticles that show great potential in pulmonary gene delivery. According to a new study published in the journal Applied Biosciences, these nanoparticles exhibit excellent transfection efficiency and stability, making
Genetic research
Researchers at West China Second University Hospital have made a significant breakthrough in the treatment of sepsis-induced lung injury (ALI) using gene therapy. According to a study published in the journal Toxins, gene therapy using LL-37 has been shown to alleviate the progression of ALI by attenuating pulmonary epithelial cell
Genetic research
Scientists at The University of Osaka have made a groundbreaking discovery in the field of gene therapy, uncovering the molecular mechanism behind genome ejection from adeno-associated virus (AAV) vectors. The findings, published in a recent study, reveal that the N-terminal region of the VP1 protein undergoes structural changes upon heating,
Genetic research
Pediatric patients undergoing hematopoietic stem cell transplant (HSCT) are at risk of developing cytomegalovirus (CMV) reactivation. A recent study published in the Transplantation and Cellular Therapy journal investigated the use of letermovir, a viral terminate inhibitor, for primary and secondary prophylaxis of CMV reactivation in pediatric patients. The study aimed
Genetic research
Scientists at Cedars-Sinai Medical Center have discovered that unchecked growth in three-dimensions (3D) in culture is a key feature of immortalized cells on the path to malignant transformation, potentially leading to cancer. According to the study, expression of genes driving 3D growth, but not 2D growth, is more specific to
Genetic research
A team of researchers from Sophia University has developed a novel approach for diagnosing liver cancer using gene expression data and machine learning techniques. The study's findings highlight the effectiveness of combining feature selection techniques with a stacking ensemble learning model to improve diagnostic accuracy and interpretability. This
Genetic research
Researchers at Heidelberg University have published a study in the journal Toxicology and Applied Pharmacology, highlighting the limited efficacy of standard cytotoxic drugs against head and neck squamous cell carcinoma (HNSCC) due to multidrug resistance (MDR). The study demonstrates that the aryl hydrocarbon receptor (AhR) signaling pathway is active in
Genetic research
Research conducted by Mongolian National University of Medical Sciences has shed light on the role of genetic factors in renal cell carcinoma (RCC). The study, which analyzed the association of TP53 and MDM2 gene polymorphisms with RCC risk among Mongolian individuals, found that individuals carrying specific genotypes showed elevated RCC
Genetic research
Researchers at the University of Utah have made a significant advancement in genomic medicine by developing the Mendelian Phenotype Search Engine (MPSE), a tool that automates the prioritization of neonatal intensive care unit (NICU) patients for whole genome sequencing (WGS). The study, published in npj Genomic Medicine, found that MPSE
Genetic research
Researchers at the National Institute of Plant Genome Research have made a significant breakthrough in improving phosphate transport and yield in rice through promoter editing. The study, published in the Plant Biotechnology Journal, demonstrates that excising the transcription inhibitor motif from the promoter of the phosphate transporter OsPHO1;2 enhances
Genetic research
New research on systemic lupus erythematosus (SLE) has identified six key genes and immune cell subtypes that play a crucial role in the pathogenesis of the autoimmune disease. The study, published in the International Journal of General Medicine, highlights the importance of memory B cells in SLE and provides a
Genetic research
Research published in Plant Physiology and Biochemistry has shown that poplar species hold considerable potential for large-scale phytoremediation efforts and genetic engineering can enhance their cadmium tolerance. A study led by researchers from Beijing Forestry University has found that the R2R3-MYB transcription factor PeRAX2 plays a crucial role in regulating
