Genetic research
Research at Duke University Medical Center has made significant advancements in the field of gene therapy, providing new hope for heart transplant patients. Scientists have developed a method of delivering a muscle-tropic recombinant adeno-associated virus (AAV) to donor hearts during normothermic ex-vivo organ perfusion (EVP) systems. This approach has shown
Genetic research
Roche Holding AG has imposed new dosing restrictions on its gene therapy treatment, ELEVIDYStm, for non-ambulatory Duchenne muscular dystrophy (DMD) patients, following the identification of two fatal cases of acute liver failure (ALF). The company has halted treatment for non-ambulatory patients in both clinical and commercial settings, citing an unfavourable
Genetic research
Researchers at the Mayo Clinic Windland Smith Rice Comprehensive Sudden Cardiac Death Program in Rochester, Minnesota, have made significant progress in the development of gene therapy as a treatment for cardiac arrhythmias. This breakthrough offers a new hope for patients suffering from cardiac arrhythmias, which are a leading cause of
Genetic research
Researchers from Indira Gandhi Delhi Technical University for Women have discovered that surface texture can enhance the performance of sliding bearings, with optimized dimple textures leading to remarkable improvements in load-carrying capacity and coefficient of friction. The study, published in the Proceedings of the Institution of Mechanical Engineers, Part J:
Genetic research
Researchers at the University Clinic in Halle Saale, Germany have presented a case of a 47-year-old male with advanced non-seminomatous germ cell tumor who carried a heterozygous pathogenic BRCA1 germline variant. The patient's family history prompted molecular testing, which revealed the BRCA1 mutation. The researchers conducted a literature
Genetic research
Scientists from the Institute of Animal Husbandry and Veterinary Medicine in Guizhou, China have conducted a comprehensive study on polydactyly, a heritable limb anomaly observed in several chicken breeds. The research aimed to elucidate the genomic variants and gene expression changes underlying this trait in the Puan Panjiang black-bone chicken,
Genetic research
Perinatal alcohol exposure has been linked to a range of adverse effects on physical, behavioral, and cognitive development in individuals with Foetal Alcohol Spectrum Disorders (FASD). A recent study examined the impact of perinatal alcohol exposure on circadian rhythms and gene expression in mice, revealing disruptions in circadian rhythmicity and
Genetic research
A novel gene-based therapy has shown significant promise in providing rapid and sustained pain relief to dogs suffering from osteoarthritis, according to a recent pilot study published in Frontiers in Veterinary Science. The trial, led by CureLab Veterinary, demonstrated that weekly injections of a p62-plasmid gene therapy, ElenaVet, resulted in
Genetic research
A new study published by researchers from Shanghai Jiao Tong University School of Medicine sheds light on the crucial mechanisms of ultraviolet (UV) radiation-induced DNA damage in skin malignancies. The study, titled "Current research on UV-induced DNA damage and its role in promoting the development of skin malignancies,"
Genetic research
Researchers at the Department of Biotechnologies, Centurion Univ Technol & Management, in Odisha, India, have conducted a comprehensive study on the genetic diversity of rice genotypes grown during Kharif 2022. The research identified significant variation in grain types among different genotypes, with 72% having extra-long slender grains, 18% having long
Genetic research
A team of researchers from Huazhong Agricultural University, led by Haiyan Fan, has made a significant breakthrough in plant science by analyzing the R2R3-MYB transcription factors in Brassica napus. The study, published in Frontiers in Plant Science, reveals the genetic diversity and functional roles of these TFs at a pan-genome
Genetic research
Chinese researchers have made a significant breakthrough in understanding the mechanisms that regulate the growth of rubber trees, a crucial crop for global natural rubber production. The study, published in The Plant Genome, reveals that the rubber tree dwarf mutant MU73397 has significantly reduced plant height and stem diameter, slower
