Genetic research
Research from Seoul National University has demonstrated the effectiveness of a dual gene therapy approach in inhibiting the growth of tumors. The therapy, which combines a herpes simplex virus-thymidine kinase (HSV-TK) gene with a small hairpin RNA (shRNA) specific for mammalian target of rapamycin (mTOR), has shown promise as a
Genetic research
Current research conducted at the University of Illinois has shed light on the dynamic changes that occur in dairy cows during the transition period from pregnancy to lactation. The study focused on the ruminal epithelium, examining the changes in gene expression, microbiota, and systemic biomarkers of metabolism and inflammation. The
Genetic research
Current research results have highlighted the efficacy of branched polyethylenimine (PEI) derivatives in gene delivery. A study by researchers at the Mashhad University of Medical Sciences found that PEI polymers can be modified to improve transfection efficiency and reduce cytotoxicity in mammalian cells. The study demonstrated that derivatives with 50%
Genetic research
Researchers have discovered that Roux-en-Y gastric bypass surgery (RYGB) regulates the expressions of microRNA-122 (miR-122) in the hypothalamus, heart, and liver, which may modulate the activities of adenosine monophosphate-activated protein kinase (AMPK), the master regulator of metabolism. The study, conducted at Keimyung University in Daegu, South Korea, used microarray analyses
Genetic research
Researchers at Himeji Dokkyo University have conducted a study on the effects of DNA methyltransferase inhibitors (DNMT inhibitors) in treating high-risk myelodysplastic syndromes (MDS) and leukemia. According to the study, DNMT inhibitors such as decitabine (DAC) induce hypomethylation of the promoter region of the cholesterol 25-hydroxylase (CH25H) gene, leading to
Genetic research
Research conducted by the University of Georgia has discovered that overexpression of the IL-13 gene can effectively prevent high-fat diet-induced obesity and insulin resistance in mice. The study aimed to assess the activity of anti-inflammatory cytokine IL-13 in blocking the negative effects of a high-fat diet on body weight, glucose
Genetic research
Current research has shown promising results for a novel method of RNA interference (RNAi) therapy using targeted microbubbles and ultrasound-targeted microbubble destruction (UTMD). This technology has the potential to provide an important therapeutic option for patients with ovarian cancer. By targeting the survivin gene, researchers were able to inhibit cell
Genetic research
Researchers from Kyoto University have developed a new method for conducting highly reliable gene expression profiling in plants using a microgram dissection method combined with on-bead cDNA library construction. This system allows for the analysis of gene expression patterns at successive 50 micrometer intervals in small regions of a plant,
Genetic research
Research published in the journal Nucleic Acids Research reveals a critical mechanism by which small RNA molecules regulate DNA methylation. The study, led by G.Q. Zhang and colleagues at New England Biolabs Inc. in Ipswich, Massachusetts, shows that microRNAs (miRNAs) bind directly to DNA methyltransferase 1 (DNMT1), inhibiting its
Genetic research
Researchers at the University of Bologna have made a groundbreaking discovery regarding the relationship between gene variants and the effectiveness of antidepressant treatments. The study, published in Molecular Diagnosis & Therapy in 2014, investigated the impact of five genetic variants on the response to either antidepressant pharmacological treatment or interpersonal
Genetic research
A new report on stem cell research, published in Cancer Gene Therapy, presents findings on using human adipose-derived mesenchymal stem cells (hAT-MSCs) to deliver therapeutic genes to brainstem gliomas. This approach, developed by researchers at Samsung Biomedical Research Institute, has shown significant therapeutic effects against brainstem gliomas in both in
Genetic research
New research from Shantou University in Guangdong, People's Republic of China, has found that in utero co-exposure to endocrine disrupting compounds such as cadmium (Cd), bisphenol A (BPA), and polychlorinated biphenyls (PCBs) can perturb fetal development. The study, published in Reproductive Toxicology, investigated the effects of co-exposure on
