Genetic research
Researchers from the Institute of Biomedical Engineering, Key Lab of Bio-Medical Diagnostics, CAS, have made a groundbreaking discovery in the field of DNA research. They have developed a novel gene expression vector based on an inverted terminal repeat of adeno-associated virus (AAV) genome. This vector, known as AAV-ITR ssDNA minivector,
Genetic research
Researchers at Zhengzhou University have developed a novel silica-polymer composite nano system for tumor-targeted imaging and p53 gene therapy of lung cancer. The system, named MB-NSi-p53-CS ternary complexes, consists of methylene blue-encapsulated amine-terminated silica nanoparticles and chondroitin sulfate. The nano system exhibited effective p53 condensation ability, efficient p53 protection profile,
Genetic research
Cancer researchers at the University of Akron have made a groundbreaking discovery in the field of cancer gene therapy. Carbon nanotubes have been widely used for drug and gene delivery due to their excellent penetrability and encapsulation efficiency. However, concerns over their toxicity have led scientists to explore alternative materials.
Genetic research
A team of researchers from the Chinese Academy of Sciences has conducted a comprehensive genome-wide phylogenetic analysis to investigate the evolutionary relationships of thiamine pyrophosphate (TPP)-dependent enzymes in plants. The study found that these enzymes are present in all domains of life, but their evolutionary dynamics in plants are
Genetic research
Research conducted by Yonsei University has discovered a key driver gene, SHFM1, in gastric cancer. The study, published in Cellular Signalling, found that SHFM1 is over-expressed in primary gastric tumors and cell lines, and plays a crucial role in the development of gastric cancer. SHFM1 was found to confer cell
Genetic research
A recent study published in Biochimica Et Biophysica Acta-Molecular Basis of Disease has found that gene transfer of interleukin-6 (IL-6) can effectively reverse obesity-induced fatty liver and insulin resistance in mice. The study, conducted by researchers at the University of Georgia, used a hydrodynamic gene delivery method to introduce the
Genetic research
A recent study published in Diabetes-Metabolism Research and Reviews investigated the frequencies of type 1 diabetes-associated gene polymorphisms and their associations with various diabetes-associated autoantibodies in Egyptian children. The research discovered that most children with diabetes were positive for the HLA(DR3)-DQA1*05-DQB1*02 (DR3-DQ2) haplotype, compared to controls.
Genetic research
Researchers from the University of Georgia have discovered that hydrodynamic delivery of the interleukin 15 (Il-15) gene can effectively prevent diet-induced obesity and obesity-associated complications in mice. The study found that Il-15 gene transfer resulted in multiple beneficial effects, including blockade of weight gain, alleviation of fatty liver, and improvement
Genetic research
Researchers from Xuzhou Medical College in the People's Republic of China have successfully constructed a conditionally replicating adenovirus pPE3-SEA that expresses the staphylococcal enterotoxin A (SEA) gene. This adenovirus vector can be used for experimental studies of tumor-targeted therapies. The study aimed to evaluate the construction and characterization
Genetic research
Gastric cancer, a leading cause of cancer deaths worldwide, has been a focus of research in recent years. A recent study conducted in central China investigated the association between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene polymorphisms and gastric cancer in the Chinese Han population. The study, published in Pharmaceutical
Genetic research
A study published in Molecular Cell has shed light on the crucial role of DNA methylation in plant and vertebrate development, genome stability, and gene regulation. Researchers from China Agricultural University discovered that the Methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. This
Genetic research
Research conducted at the University of Alberta investigated the link between melanoma antigen (MAGE) gene expression and cancer outcomes. The study utilized transcriptomic and survival data from 26 cancer studies through the cBio Cancer Genomics Portal to examine the dysregulation of 34 MAGE genes in cancer. The findings revealed that
