Scientists
Researchers from the Repatriation General Hospital in Sydney, Australia, have investigated the potential of genetic markers to predict response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer (mCRC) patients. The study analyzed tumor tissues from 118 mCRC patients who underwent FOLFOX treatment and found that specific genetic alterations and
Scientists
Scientists at Kyushu University, Fukuoka, Japan, have made a significant breakthrough in cancer therapy by creating an oncolytic adenovirus that enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells. This innovative approach involves the use of a human telomerase reverse transcriptase (hTERT)-promoter-dependent oncolytic adenovirus,
Scientists
Researchers at the University of Texas M.D. Anderson Cancer Center have conducted a study to investigate the role of c-Jun-NH2-kinase (JNK)-1 in ovarian carcinoma. The study aimed to assess the functional, clinical, and biological significance of JNK-1 in ovarian cancer. The researchers found a significant association between pJNK
Scientists
Researchers from Ohio State University have uncovered a crucial link between the inflammation-associated cytokine interleukin-6 (IL-6) and oncogenesis in cholangiocarcinoma, a type of liver cancer. Their study found that IL-6 can regulate the activity of DNA methyltransferase-1 (DNMT-1) and expression of methylation-dependent tumor suppressor genes by modulating specific microRNAs (miRNAs)
Scientists
Researchers in Cardiff, UK, have developed a highly efficient method for genetically modifying primary chronic lymphocytic leukemia (CLL) cells using a VSVG pseudotyped lentiviral vector. This technique, detailed in a study published in Haematologica, allows for the introduction and analysis of genes in non-dividing CLL cells. The researchers found that
Scientists
A recent study published in the International Journal of Cancer Journal International Du Cancer has shed light on the key role of Snail in ovarian cancer metastasis. Scientists in Shanghai, People's Republic of China, have found that knockdown of Snail expression suppresses the activity of matrix metalloproteinases (MMPs)
Scientists
Scientists from the Institute of Genetics and Biophysics Adriano Buzzati-Traverso have made a significant discovery in cancer gene therapy, revealing a new approach to inhibit tumor angiogenesis using a variant of placental growth factor (PlGF). The researchers generated a PlGF1 variant, named PlGF1-DE, which is unable to bind and activate
Scientists
Recent research published in Toxicology Letters suggests that dietary polyphenols may play a crucial role in the epigenetic regulation of gene expression in MCF7 breast cancer cells. The study, conducted by J. Paluszczak and colleagues at Poznan University of Medical Sciences, investigated the effect of various phytochemicals on the activity
Scientists
Researchers have made significant progress in developing adenoviral vectors for cancer gene therapy, with a focus on overcoming the toxicity of therapeutic genes that inhibit vector production. A recent study published in Virology compared binary and single-inducible vectors expressing truncated E2F-1, a protein that induces cancer cell apoptosis but is
Scientists
Researchers at the University of Massachusetts have made a groundbreaking discovery in the field of leukemia research, detailing the role of the tumor suppressor gene phosphatase and tensin homolog (PTEN) in chronic myeloid leukemia (CML) and B-cell acute lymphoblastic leukemia (B-ALL). According to the study published in Blood, PTEN is
Scientists
Researchers in the United States have published a study on a new treatment for prostate cancer using an oncolytic measles virus. The virus, which expresses the sodium iodide symporter, has shown significant antitumor activity against prostate cancer cells. In vitro experiments demonstrated the virus's ability to effectively concentrate
Scientists
According to a recent study published in the journal Leukemia & Lymphoma, the activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Researchers from Southwestern Medical Center, led by D. Dumka, discovered that dasatinib, a dual Src/Abl tyrosine kinase inhibitor, activates the p38
