Highly active antiretroviral therapy

Tuberculosis Preventive Treatment for Pregnant People With HIV: A Modeling Analysis of Clinical Benefits and Risks

Research conducted by Massachusetts General Hospital and the International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network has evaluated the effectiveness of tuberculosis preventive treatment (TPT) for pregnant people with human immunodeficiency virus (HIV) in South Africa. The study used a microsimulation model to compare five TPT strategies among pregnant

Antiretroviral agents

New Study Reveals Effective HIV Prevention Strategy for Young Adults in Rural South Africa

A new cluster-randomized stepped-wedge trial in South Africa has shown that community-based peer navigators can effectively mobilize demand for HIV prevention and care among young adults in rural areas. The study, conducted in collaboration with the Africa Health Research Institute, aimed to investigate whether a tailored approach to HIV prevention

HIV

High HIV Viral Suppression Rates Achieved in Low- and Middle-Income Countries

Recent research conducted at Imperial College London has made significant breakthroughs in the treatment of HIV/AIDS. The study assessed the effectiveness of the WHO-recommended first-line dolutegravir-based antiretroviral therapy (ART) in programmatic settings in low- and middle-income countries (LMICs). The research revealed that adults receiving this treatment achieved high viral

Highly active antiretroviral therapy

Breakthrough in HIV/AIDS Treatment: Lenacapavir Shown to be Effective Against Multidrug-Resistant HIV-1

Researchers from Ohio State University have made a significant discovery in the field of HIV/AIDS treatment, revealing that Lenacapavir (LEN), a new, first-in-class, long-acting HIV-1 capsid-targeting inhibitor, exhibits high potency against all major HIV-1 subtypes, including variants resistant to current antiretroviral therapies. The study, published in the ACS Medicinal

HIV patients

Age-Associated Expansion of HIV/SIV Reservoirs Impacts HIV/AIDS Treatment

Research at the University of Nebraska Medical Center has identified a concerning trend in the aging HIV population. With over 50% of people living with HIV in the United States now over the age of 50, the study reveals that the immune system's dysfunction with age contributes to

HIV

Immune Cell Architecture of HIV Control Revealed

A study published in Frontiers in Immunology has uncovered the complex immune cell architecture responsible for HIV control in a subset of individuals known as HIV controllers. Researchers from Radboud University Medical Center in Nijmegen, Netherlands, analyzed immune cells from 54 HIV controllers, including 21 elite controllers, and compared them

HIV

Tuberculosis Preventive Treatment for Pregnant People With HIV: A Modeling Analysis of Clinical Benefits and Risks

HIV

Growth Outcomes in HIV-Exposed and Uninfected Children in South Africa

Research conducted by the University of the Witwatersrand in Johannesburg, South Africa, has found that children who are HIV-exposed and uninfected (CHEU) have similar growth outcomes to those who are HIV-unexposed and uninfected (CHUU) up to 2 years of age. However, the study revealed high prevalence of stunting in both

HIV

Rabies Outbreak in HIV-Positive Woman Raises Concerns About Public Health in Africa

Researchers at the University of Zambia have reported a rare case of rabies in a pregnant woman living with HIV. The woman, in her eighth pregnancy, presented with neurological symptoms after being bitten by dogs 20 days prior. Despite receiving antiretroviral therapy and post-exposure prophylaxis, the disease rapidly progressed to

HIV

Researchers at Washington University Target HIV/AIDS with Breakthrough Discovery on Immune System Diseases and Conditions

Researchers from Washington University have made a groundbreaking discovery regarding the immune system's role in HIV-1 persistence. According to their research, despite antiretroviral therapy, HIV-1 mainly persists in memory CD4+ T cells in people living with HIV-1. The study found that most long-lived viral reservoir cells are infected

HIV

Persistent Inflammation in HIV-Positive Individuals Highlights Need for Tailored Strategies

Researchers from Mangosuthu University of Technology have shed light on the persistent inflammation in HIV-positive individuals, despite antiretroviral therapy (ART). The study, published in the African Journal of Laboratory Medicine, analyzed retrospective laboratory results from 275 individuals, aged 0-39 years, treated at a tertiary hospital in South Africa. The findings

HIV patients

INSTI-Based Antiretroviral Therapy May Be Linked to Weight Gain in HIV Patients

A study conducted by researchers at the Southern University of Science and Technology (SUSTech) in Shenzhen, China, suggests that integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) may be associated with weight gain in people living with HIV (PLWH). The research, published in the Clinical Infectious Diseases journal, analyzed

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