Cancer research
Researchers at Massachusetts General Hospital have made significant progress in the development of immunotherapies for IDH-mutant gliomas, a type of brain tumor that is notoriously challenging to treat. According to a new study published in the journal Cancers, these tumors have a unique immunosuppressive tumor microenvironment (TME) that hinders the
Cancer research
Researchers at the University of Texas MD Anderson Cancer Center have published a new report on the use of bezlotoxumab, a monoclonal antibody, in treating recurrent clostridioides difficile (CDI) infection in pediatric stem cell transplant (SCT) patients. The study found that bezlotoxumab, when used in conjunction with antibiotic therapy, was
Cancer research
Researchers at Hubei Cancer Hospital have initiated a clinical trial aimed at reversing resistance to first-line PD(L)-1 monoclonal antibody combination therapy in stage IV non-small cell lung cancer patients with negative driver genes. The trial, registered with the Chinese Clinical Trial Registry (ChiCTR), seeks to explore the efficacy
Cancer research
Researchers from Fudan University have explored the use of DNA nanostructures-based materials to improve the therapeutic efficacy of cancer immunotherapy. The study aims to address the challenges of low drug loading, imprecise targeting, and non-specific releasing in current cancer treatments. The researchers designed a DNA nanostructure-based delivery system that can
Cancer
Researchers from Johns Hopkins University have made a groundbreaking discovery in the field of cancer immunotherapy. The study, published in Nature Communications, presents a novel approach to harnessing the power of messenger RNA (mRNA) to generate a potent immune response against cancer. By incorporating lipid nanoparticles into a nanofiber-hydrogel composite,
Cancer
As the prevalence of cancer rises globally, with an estimated 35 million new cases predicted by 2050, researchers are exploring innovative treatment options, such as cancer immunotherapy. This form of treatment harnesses the body's immune system to fight cancer cells, offering increased life expectancy beyond traditional treatments. A
Cancer
Research published in the journal Nature Communications by a team of scientists from the University of California Davis has revealed an unexpected discovery in the regulation of human Fas Ligand (FasL) in the context of solid cancer immunotherapy. The study found that humans are more likely to develop cancers than
Cancer
Researchers at Shanghai Jiao Tong University have made significant findings in the field of cancer gene therapy, discovering that circKCNK2 plays a crucial role in osteolytic bone metastasis of renal cell carcinoma (RCC). The study, which was funded by the National Natural Science Foundation of China and the Precision Research
Cancer
Dr. Rubul Mout, a research fellow at Harvard Medical School and Boston Children's Hospital, has led a groundbreaking scientific team that has developed AI-designed synthetic proteins capable of significantly enhancing cancer immunotherapy. This innovation utilizes the Notch signalling pathway to produce large-scale T-cells in simpler, suspension-based environments, making
Cancer research
Research conducted at Johns Hopkins University has shed light on the effects of immunotherapy on bone marrow interactions in patients with acute myeloid leukemia (AML). The study employed a multiomic approach, combining single-cell RNA sequencing with single-cell spatial transcriptomics, to analyze the interactions between leukemia cells and immune cells post-immunotherapy
Cancer
Researchers from Uppsala University in Sweden have conducted a study to understand the protective immunity against SARS-CoV-2 in children with cancer or hematological diseases. The study, published in Frontiers in Immunology, aimed to characterize the immune response in these patients and investigate how their compromised immune systems affect their ability
Cancer
Researchers at the Barbara Ann Karmanos Cancer Institute are conducting a Phase 1 clinical trial to study the safety of metformin when combined with chemotherapy and/or immunotherapy in patients with solid tumor cancers. The trial aims to evaluate the toxicities of metformin at multiple dose levels and determine the
