Cancer
Recent research findings from a study conducted by the National Cancer Institute (NCI) have shed new light on the treatment of carcinomas. The study, which was published in Future Oncology, explored the use of sacituzumab govitecan (SG), a TROP2-directed antibody-drug conjugate, in combination with atezolizumab, an immunotherapeutic agent. The research
Cancer
Cancer has long been known to compromise the immune system, affecting both the peripheral immune system and the local tumor microenvironment. Current immunotherapies have shown limited efficacy due to severe immunosuppression. However, researchers from Amrita Vishwa Vidyapeetham have made a groundbreaking discovery, developing an immunologically engineered injectable immunehydrogel (iHG) that
Cancer
Scientists at Vanderbilt University have made a significant breakthrough in cancer immunotherapy by developing a modular approach to enhance the potency of systemically administered cancer treatments. By conjugating a stimulator of interferon genes (STING) agonist to anti-albumin nanobodies, researchers have created a technology that prolongs the circulation of the agonist
Cancer research
Researchers at the Medical University of South Carolina's Hollings Cancer Center have made a significant breakthrough in the treatment of acute myeloid leukemia (AML), a fast-growing and aggressive form of blood cancer. Led by pediatric hematologist-oncologist and bone marrow transplant expert Sophie Paczesny, M.D., Ph.D., the
Cancer research
Researchers from Peking Union Medical College Hospital have conducted a comprehensive analysis of single-cell and bulk RNA sequencing data to shed light on the role of antigen-presenting and processing fibroblasts (APPFs) in the regulation of tumor immune microenvironment in gastric cancer (GC). The study identified five APPF-related genes (APPFRGs) that
Cancer research
Researchers at the University of Chicago have made significant strides in the treatment of recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) using immune checkpoint inhibitors and other novel therapeutics. Despite an improvement in survival rates, only 15%-19% of patients remain alive at four years, highlighting the
Cancer research
Research findings from a phase Ib/II trial have revealed promising results for a novel combination therapy in treating metastatic estrogen receptor positive breast cancer. The study, conducted at Vanderbilt University Medical Center, evaluated the clinical activity and safety of atezolizumab in combination with either cobimetinib or idasanutlin in patients
Cancer research
Researchers at the University of Rzeszow in Poland have made significant breakthroughs in cancer gene therapy using nanoparticles to target and treat glioblastoma, a highly aggressive and difficult-to-treat form of brain cancer. Traditional treatments have been limited by the blood-brain barrier, tumor cell infiltration, and heterogeneity, but nano-based technologies have
Cancer
Investigators at Gannan Medical University in the People's Republic of China have discovered a novel hydrazide-based HDAC3 inhibitor, compound 8ae, which demonstrates potent HDAC3 inhibitory activity and significant antiproliferative activity against five types of cancer cells. The compound also exhibits favorable pharmacokinetic properties and has been shown to
Cancer
Cancer immunotherapy has become a significant area of research, utilizing the immune system to selectively destroy malignant cells. However, its effectiveness is often undermined by inadequate immune system activation, immune evasion by tumors, and off-target damage. Researchers at Aligarh Muslim University have published a comprehensive review highlighting the potential of
Cancer
Scientists at the Institute for Cancer Research and Treatment (IRCCS) Santa Lucia Foundation in Rome, Italy, have published a seminal paper exploring the transformative impact of genomics and artificial intelligence (AI) in precision oncology. According to the research, the increasing burden of cancer globally necessitates innovative approaches for diagnosis, prognosis,
Cancer research
New research on cancer gene therapy has shed light on the potential of alphavirus-based vectors in reprogramming macrophages to fight cancer. The study, published in the Journal of Immunology Research, indicates that these vectors can alter cytokine and chemokine profiles in cancer cells, reducing immunosuppressive factors and increasing inflammatory mediators.
