Immunotherapy

Cancer research

Epigenetic Therapy Sensitizes Anti-pd-1 Refractory Head and Neck Cancers To Immunotherapy Rechallenge

In a significant breakthrough, researchers at Yale University have discovered that epigenetic therapy can sensitize anti-pd-1 refractory head and neck cancers to immunotherapy rechallenge. The study, published in the Journal of Clinical Investigation, found that low-dose 5-azacytidine (5-aza) combined with durvalumab and tremelimumab after progression on immune checkpoint blockade (ICB)

Cancer research

Epigenetic Silencing of DNA Sensing Pathway Impacts Cancer Immunotherapy

Researchers from the Greehey Children's Cancer Research Institute have discovered a significant role of the transcription factor FOXM1 in shaping the tumor immune landscape. According to the study, FOXM1 creates an immune-suppressive tumor microenvironment by inhibiting the expression of stress ligands on cancer cells, thereby blocking natural killer-

Cancer

Whole-Body CT Scanning Radiation Enhances Anti-Tumor Effect of Immune Checkpoint Inhibitors

Tianjin Medical University Cancer Institute & Hospital researchers have investigated the impact of frequent whole-body CT scans during immune checkpoint inhibitor (ICI) therapy on patients' anti-tumor immunity in stage IV non-small cell lung cancer (NSCLC) patients. Their study found that the more frequent CT scans during ICI treatment, the

Cancer

Novel Therapeutic Vaccine Combination Shows Promise in Treating HPV-Associated Malignancies

Researchers from the National Cancer Institute (NCI) have published a study on a combination therapy that shows significant promise in treating human papillomavirus (HPV)-associated malignancies. The study, titled "Combination of HDAC inhibition and cytokine enhances therapeutic HPV vaccine therapy," was published in the Journal for ImmunoTherapy of

Cancer

Researchers Identify Key Regulator of NKT Cell Therapy for Cancer

Researchers at Texas Children's Cancer & Hematology Center have identified a crucial regulator of natural killer T (NKT) cell therapy for cancer treatment. The team developed a CRISPR/Cas9-based mutagenesis screen, which revealed that PRDM1, a transcription factor, plays a vital role in regulating NKT cell memory differentiation

Cancer

Combination Chemotherapy Regimens Show Promise in Treating Advanced Lung Cancer

A new study published in the Journal of the National Comprehensive Cancer Network has revealed that combination chemotherapy regimens, particularly those involving immunotherapy and anti-angiogenic agents, show significant promise in treating advanced EGFR-mutant non-small cell lung cancer (NSCLC) after failure of EGFR-tyrosine kinase inhibitors (EGFR-TKIs). The study, conducted by researchers

Cancer research

Evolving Treatment Strategies for Resectable Non-Small Cell Lung Cancer

A new report outlines the shifting landscape of treatment options for patients with resectable non-small cell lung cancer (NSCLC), highlighting two frequently encountered dilemmas in clinical practice. According to a study published in Annals of Surgical Oncology, research has shown that treatment strategies for NSCLC have evolved significantly over the

Cancer

mRNA-Based Vaccines Show Promise in Cancer Treatment, but Lymphatic Transport and Delivery Limit Their Application

Researchers from Xuzhou Medical University in Jiangsu, People's Republic of China, have made a breakthrough in the development of mRNA-based vaccines for cancer treatment. The team has created a novel mRNA nanovaccine that uses a hybrid membrane of dendritic cells and bacterial membrane to enhance cancer immunotherapy. The

Cancer research

Brain Cancer Canada Awards $68,000 Research Grant for Life-Changing Anti-Cancer Vaccine

Brain Cancer Canada is pleased to announce the awarding of a $68,000 research grant to Dr. Aru Narendran and Dr. Patrick Sipila at The University of Calgary and Alberta Children's Hospital, marking a significant step towards developing a novel immunotherapy approach for the most aggressive childhood brain

Cancer research

Repurposing Anti-Viral Vaccines for Solid Tumors

Researchers at the National Cancer Institute (NCI) have discovered a potential new approach to treating solid tumors using licensed anti-viral vaccines. The study involved the use of Shingrix, Gardasil-9, and Spikevax vaccines, which are commonly used to prevent shingles, HPV, and COVID-19, respectively. By delivering these vaccines directly into tumors,

Cancer research

Advances in Cancer Treatment: Targeted Therapies and Immunotherapies Show Promising Results

Current research on cancer treatment has shown significant improvements in outcomes for patients, thanks to the shift from traditional chemotherapy to targeted therapies and immunotherapies. Regulatory agencies have approved several targeted therapies for specific genetic mutations, leading to better results for various diseases. A recent study conducted at the University

Cancer research

Breakthrough in Cancer Research: DHODH Plays Crucial Role in Immune Evasion

Researchers from Cedars-Sinai Medical Center have made a significant discovery in the field of cancer research. According to a study published in Nature Communications, the enzyme dihydroorotate dehydrogenase (DHODH) plays a crucial role in cancer cells' ability to evade immune destruction. The study found that inactivation of DHODH increases