Cancer prevention
A new study conducted at the Catholic University of Korea, in collaboration with Seoul St. Mary's Hospital, has shed light on the role of cancer-associated fibroblasts in the ovarian cancer microenvironment. According to the research, cancer-associated fibroblasts (CAFs) contribute to immunosuppression in ovarian cancer by upregulating indoleamine 2,
Immunotherapy
Regulatory T cells, a crucial subset of immune cells, play a vital role in preventing excessive inflammation and autoimmune disorders. However, the precise molecular process driving their activation has been unclear, hindering the development of therapeutic interventions for autoimmune and inflammatory diseases. A recent study by St. Jude Children'
Cancer treatment
Researchers at Xiamen University in China have introduced a novel nanomedicine, DBEP@alpha MV, which has shown promise in enhancing NK cell-based immunotherapy for cancer treatment. The study, published in the Journal of Chemical Engineering, aimed to develop a strategy for targeting post-treatment residual hepatocellular carcinoma. The research revealed that
Cancer treatment
Researchers at Shaanxi Provincial People's Hospital, in collaboration with other institutions, have made a groundbreaking discovery in the field of bladder cancer. By integrating expression quantitative trait loci (eQTL) data with Mendelian randomization (MR) analysis, the team identified a key biomarker, Tripartite Motif Containing 59 (TRIM59), which plays
Cancer treatment
A multicenter study conducted at Teine Keijinkai Hospital in Sapporo, Japan, has identified a modified tumor marker score that can help predict treatment outcomes for patients with unresectable hepatocellular carcinoma (HCC). The study, published in the journal Liver Cancer, found that the score, which incorporates alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin
Cancer treatment
Researchers at Shaanxi Provincial People's Hospital, in collaboration with other institutions, have made a groundbreaking discovery in the field of bladder cancer. By integrating expression quantitative trait loci (eQTL) data with Mendelian randomization (MR) analysis, the team identified a key biomarker, Tripartite Motif Containing 59 (TRIM59), which plays
Colorectal cancer
A new study from the Second Affiliated Hospital of Soochow University in Suzhou, People's Republic of China, has evaluated the efficacy of PRaG therapy, a combination of programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) inhibitors, radiotherapy, and granulocyte-macrophage colony-stimulating factor, in overcoming resistance
Colorectal cancer
A new report from the Affiliated Hospital of Yanbian University in China has shed light on the potential of the cGAS-STING pathway in treating colorectal cancer (CRC). The pathway, which plays a dual role in CRC, has been identified as a promising target for cancer immunotherapy. Researchers have discovered that
Cancer treatment
Current studies on oncology, specifically acute myeloid leukemia, have revealed a significant disparity between the effectiveness of immunotherapy in lymphoid malignancies and its lackluster performance in acute myeloid leukemia. Despite dramatic improvements in outcomes for lymphoid malignancies, such as B cell cancers, AML has not experienced a comparable breakthrough. Researchers
Cancer
CatalYm, a world leader in neutralizing GDF-15 in cancer and cachexia, presented updated long-term data from its ongoing GDFATHER-1/2a trial at the European Society of Medical Oncology (ESMO) Congress 2025. The data provide further evidence that Growth Differentiation Factor-15 (GDF-15) blockade by visugromab can reverse resistance to PD-(L)
Cancer research
A recent study published in the Journal of Experimental & Clinical Cancer Research has shed light on the mechanisms of immunosuppression in ovarian cancer, a type of cancer that affects women's reproductive organs. Researchers from Shanghai First Maternity and Infant Hospital in China have discovered a novel feedback
Cancer treatment
Researchers at the Federal University of Sergipe, Sao Cristovao, Brazil, have made significant findings on the integration of nanotechnology with natural products for developing cancer treatments and immunotherapies. Their study, published in the Beilstein Journal of Nanotechnology, reveals that nanotechnology provides significant advantages in controlling drug release, enhancing stability, and
