Cancer research
Researchers at San Matteo Hospital Foundation have described new data in non-small cell lung cancer treatment, highlighting the potential benefits of combining immunotherapy and non-ablative radiation therapy. According to a case report published in Frontiers in Oncology, the association of immunotherapy and non-ablative radiation regimens may represent a safe and
Cancer research
Researchers at Taiyuan University of Technology have made a significant breakthrough in the fight against cancer, developing a novel nanoparticle system that targets cancer stem cells and tumor-associated macrophages to promote immunotherapeutic efficacy. According to a study published in Colloids and Surfaces B-biointerfaces, the team successfully synthesized a mannose, polyethylene
Cancer
New research from the Keck School of Medicine of USC has shed light on the mechanisms behind human papillomavirus (HPV)-linked cancers, specifically the role of a signaling protein, Interleukin-23 (IL-23), in undermining the body's defenses. The study found that blocking IL-23 boosts the effectiveness of experimental treatments
Cancer
Immunotherapy has transformed cancer treatment by leveraging the body's natural defenses to target and destroy cancer cells. However, evaluating its effectiveness presents unique challenges. Advanced imaging techniques play a crucial role in guiding decisions and improving patient outcomes in immunotherapy clinical trials. These techniques, including immunoPET, offer a
Cancer research
A breakthrough in gastric cancer treatment has been reported by researchers at Nanjing Medical University in Jiangsu, People's Republic of China. A 35-year-old female patient with recurrent and metastatic gastric cancer, who had previously failed multiple therapies, including chemotherapy and immunotherapy, achieved complete remission after undergoing a novel
Cancer
Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have made a groundbreaking discovery in the fight against metastatic kidney cancer, developing an "off-the-shelf" immunotherapy called AlloCAR70-NKT. This innovative treatment uses specially engineered immune cells to attack tumors and reprogram their protective environment, offering a promising next-generation strategy
Cancer research
Researchers from Princess Margaret Cancer Centre have published the results of a phase 3 study, LEAP-008, investigating the efficacy of lenvatinib plus pembrolizumab versus docetaxel in patients with metastatic non-small cell lung cancer (NSCLC) that had progressed on anti-programmed cell death protein 1 or anti-programmed cell death ligand 1 therapy
Cancer
Researchers at Nanjing University of Posts and Telecommunications in Nanjing, People's Republic of China, have discovered that amlodipine, a widely used antihypertensive medication, has immunomodulatory effects that can enhance dendritic cell maturation and anti-tumor immunity. The study, published in Molecular Therapy, found that amlodipine promotes DC maturation, increases
Cancer research
Researchers at the National Cancer Center in Japan have identified common cancer antigens that can be targeted for immunotherapy in colon cancer patients, particularly those with stage IV colorectal cancer and liver metastases. According to a new report published in the International Journal of Molecular Sciences, the team analyzed expression
Cancer research
Researchers at Tianjin University have conducted a retrospective cohort study to evaluate the effectiveness of atezolizumab combined with etoposide and platinum (EP) chemotherapy compared to EP alone as first-line treatment in patients with extensive-stage small cell lung cancer (ES-SCLC). The study included 95 patients diagnosed with ES-SCLC at Tianjin Chest
Cancer research
Researchers from the Cancer Hospital of China Medical University have made significant findings in the field of cancer gene therapy, particularly in the treatment of melanoma. According to their study, published in the journal Frontiers in Immunology, nano-immunotherapy has emerged as a promising approach for melanoma treatment. By leveraging nanotechnology,
Cancer research
A study published in Frontiers in Cellular and Infection Microbiology has made significant progress in understanding the relationship between the gut microbiome and immunotherapy response in lung cancer patients. Researchers at the Cancer Hospital of China Medical University conducted a comprehensive analysis of publicly available global metagenomic datasets to identify
