Cancer research
Research conducted at Beni Suef University in Egypt has highlighted the potential of lipid nanoparticles (LNPs) in delivering nucleic acid therapy for cancer treatment. According to the study, LNPs can safely and efficiently deliver therapeutic molecules directly to immune cells, enhancing their bioavailability and therapeutic impact. The use of LNPs
Immunotherapy
Researchers at the Max Delbruck Center, led by Professor Young-Ae Lee, have made a groundbreaking discovery in understanding why some children with peanut allergies respond well to oral immunotherapy, while others do not. The team analyzed blood samples from 38 children undergoing oral desensitization and found significant differences in molecular
Cancer
MAIA Biotechnology, a clinical-stage biopharmaceutical company, has announced that the European Patent Office has granted a patent covering a portfolio of ateganosine-based analogues for telomere-targeting anticancer therapy. This patent is the result of the innovative work of MAIA's Chief Scientific Officer Sergei M. Gryaznov, PhD, and Scientific Advisory
Cancer
Researchers have detailed new data on gastric cancer, highlighting the complex interplay between the microbiota and the development of the disease. According to a study published in the Journal of Life, the composition of the gastric microbiota plays a significant role in shaping the gastric microenvironment and influencing disease progression.
Cancer research
Researchers at the University of Tubingen in Germany have made a breakthrough discovery in the treatment of triple negative breast cancer (TNBC), a particularly aggressive and hard-to-treat form of the disease. The study, recently published in Frontiers in Immunology, found that non-invasive physical plasma (NIPP) can induce cytotoxicity and activate
Cancer research
Researchers have made significant progress in developing targeted delivery systems for therapeutic cancer vaccines, which has improved their efficacy in treating cancer. According to a recent study published in the International Journal of Molecular Sciences, current treatments such as surgery and targeted therapy have limited effectiveness due to diagnostic technology
Cancer research
Elpis Biopharmaceuticals, a clinical-stage cell therapy company, has announced a partnership with the National Cancer Centre Singapore (NCCS) to support collaborative cell therapy research and clinical trials for the treatment of various cancers, including colorectal, pancreatic, and ovarian cancers. The partnership aims to accelerate the development of next-generation cell therapies
Cancer research
A recent observational study conducted in Japan has evaluated the effectiveness and safety of nivolumab plus chemotherapy in untreated patients with advanced or recurrent gastric cancer. The study found that the objective response rate (ORR) was 65.6% and the median real-world progression-free survival (rwPFS) was 6.9 months. The
Cancer
Research investigators from the University of Perugia have dissected the developmental pathways and functional specializations of diverse dendritic cell (DC) subsets, highlighting their critical role in antitumor immunity. By integrating mechanistic insights with clinical advances, this study underscores the potential of context-aware, subset-specific DC interventions to overcome immune suppression and
Cancer
Researchers from the Roswell Park Comprehensive Cancer Center in Buffalo, New York, have published a new study on the efficacy of immunotherapy in patients with myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML). The study, which was funded by the Roswell Park Alliance Foundation, the University at Buffalo, and the National
Cancer
Researchers have developed and characterized a therapeutic modality called FLT3L-Fc NG2LH, which improves human FLT3L pharmacokinetic (PK) properties by fusing it with a modified fragment crystallisable (Fc) domain of IgG1. This therapeutic modality has limited binding to Fc gamma receptors and fails to elicit antibody-dependent cellular cytotoxicity and cellular phagocytosis.
Cancer research
Research from Shanghai University of Traditional Chinese Medicine has identified a novel type of regulated cell death in colorectal cancer (CRC) called disulfidptosis. Scientists discovered that disulfide imbalance, which is caused by excessively high intracellular levels of cystine, can induce disulfidptosis. This study suggests that targeting disulfide imbalance could be
