Infection
A groundbreaking study published in The New England Journal of Medicine has demonstrated the efficacy of a vaccine against Salmonella Paratyphi A infection, a major contributor to enteric fever that causes over 100,000 deaths and 8 million disability-adjusted life years annually. The Oxford-led research used a controlled human infection
Cardiac patients
Researchers at Galgotias University have identified significant risks and complications associated with sepsis in patients undergoing cardiac surgery. The study, published in the journal Perioperative Medicine, highlights the importance of standardized diagnostic criteria to improve recognition and management of post-operative infections in this high-risk group. According to the research, surgical
Bronchiectasis
Researchers from Kunming, People's Republic of China, have detailed new data in Lung Diseases and Conditions - Bronchiectasis. The study collected and analyzed clinical data and lower respiratory tract pathogen detection results from 410 patients with bronchiectasis admitted to the Anning First People's Hospital Affiliated to
Dengue fever
Manipur has been grappling with a sudden surge in dengue infections, with health officials confirming over 2,500 cases in Imphal West alone. The state's health department has expressed concern over the increased numbers, with experts attributing the rise to prolonged monsoon rains, ideal breeding conditions for the
Epilepsy
Researchers from the Children's Hospital of Fudan University in Shanghai, People's Republic of China, conducted a retrospective analysis of inpatients with febrile infection-related epilepsy syndrome (FIRES) to evaluate the clinical efficacy and long-term functional prognosis of vagus nerve stimulation (VNS) combined with ketogenic diet (KD). The
Antibiotics
A new study conducted by researchers at McMaster University in Canada has demonstrated the feasibility and safety of using prophylactic irrigation solutions and topical antibiotics to prevent periprosthetic joint infection (PJI) in total joint replacement surgeries. The study, titled "The Prospective Randomized EValuation of Emerging Novel Treatments for Infection
Infection
The European Medicines Agency (EMA) has granted Orphan Drug Designation (ODD) to RBD1016 for the treatment of HDV infection, a rare and severe form of viral hepatitis. This designation is a significant regulatory milestone that enhances the development and commercial potential of RBD1016, a siRNA drug candidate designed to selectively
Infection
The European Medicines Agency (EMA) has granted Orphan Drug Designation (ODD) to RBD1016 for the treatment of HDV infection, a rare and severe form of viral hepatitis. This designation is a significant regulatory milestone that enhances the development and commercial potential of RBD1016, a siRNA drug candidate designed to selectively
Hospital patients
According to a recent global systematic review and meta-analysis of over 20,000 patients, antimicrobial resistance (AMR) is highly prevalent within hospital settings and associated with increased in-hospital mortality worldwide. The study, conducted by researchers at the University of Leicester, aimed to quantify the prevalence and risk of mortality associated
Cytokines
A new study examining the effects of cytokine-filtered continuous renal replacement therapy (CRRT) on sepsis patients reveals that hemogram-derived indices, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), may reflect treatment-related effects rather than disease progression. The research, conducted at a single tertiary care center in Istanbul, Turkey,
Infection
In a recent study conducted at Bharti Vidyapeeth Deemed University Medical College, researchers explored the potential of monocyte distribution width (MDW) as an early sepsis marker in intensive care unit (ICU) patients. The study utilized the DxH900 Haematology Analyzer to measure MDW in 74 patients suspected of having sepsis. Results
Infection
Researchers from Imperial College London have developed a near point-of-care, LAMP-based diagnostic platform for malaria diagnosis using capillary blood. This platform has shown high sensitivity and specificity in detecting Plasmodium falciparum infections, including asymptomatic and submicroscopic cases, in African endemic countries. The study's findings have significant implications for
