Gene therapy
Research conducted at Anhui University of Science and Technology in Huainan, People's Republic of China, has led to a groundbreaking discovery in the field of biotechnology and gene therapy. The study, published in Signal Transduction and Targeted Therapy, identified peroxiredoxin 4 (PRDX4) as a critical regulator in the
Genes
Researchers from the First Affiliated Hospital of Army Medical University in Chongqing, People's Republic of China, have conducted a comprehensive bioinformatics analysis to identify key genes associated with chronic obstructive pulmonary disease (COPD) and macrophage polarization or mitochondrial dysfunction. The study utilized data from three gene expression datasets
Macrophages
Advances in immunotherapy, particularly the use of chimeric antigen receptor (CAR) technology, have revolutionized the treatment of hematological diseases. Recent research has highlighted the potential of induced pluripotent stem cell (iPSC) technology to develop renewable sources for CAR-based therapies, overcoming scalability and donor variability challenges. This review explores the latest
Macrophages
Advances in immunotherapy, particularly the use of chimeric antigen receptor (CAR) technology, have revolutionized the treatment of hematological diseases. Recent research has highlighted the potential of induced pluripotent stem cell (iPSC) technology to develop renewable sources for CAR-based therapies, overcoming scalability and donor variability challenges. This review explores the latest
Epigenetic inheritance
Research conducted at Central South University in Changsha, People's Republic of China, has shed light on the mechanisms driving macrophage senescence after spinal cord injury (SCI). The study, published in the Journal of Advanced Research, highlights the role of ubiquitously transcribed tetratricopeptide repeat X chromosome (UTX) in regulating
Tuberculosis
Researchers from the Tongji University School of Medicine in Shanghai, China, have made a groundbreaking discovery on how Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis, manipulates host responses to promote its intracellular survival. According to their study, published in Nature Microbiology, Mtb uses a metabolite called linoleic acid to
Biochemistry
Research at the Second Medical Center of Chinese PLA General Hospital has shown that MLN4924, a novel small molecule inhibitor of neddylation, possesses anti-inflammatory properties and promotes cardiomyocyte autophagy. The study aimed to investigate the effects of MLN4924 on the formation of foam cells, which play a critical role in
Tuberculosis
A study published in the journal Redox Report presents fresh data on the treatment of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). The research highlights the potential of Host-directed therapy (HDT) in shortening treatment duration and limiting resistance to drugs. The study focuses on the flavonoid Scutellarin (SCU)
Tuberculosis
Researchers from the University of Sydney employed whole-slide spatial proteomics to map immune cell organization in tuberculosis-affected human lung tissues. The study's findings suggest that spatial isolation of macrophages from effector lymphocytes may help temper inflammation and prevent lesion progression to necrosis, while also enabling immune evasion by
Tuberculosis
Researchers from the University of Sydney employed whole-slide spatial proteomics to map immune cell organization in tuberculosis-affected human lung tissues. The study's findings suggest that spatial isolation of macrophages from effector lymphocytes may help temper inflammation and prevent lesion progression to necrosis, while also enabling immune evasion by
Tuberculosis
A new study published in the journal PLOS Pathogens has shed light on the critical mechanisms of pulmonary tuberculosis (TB) transmission among humans. The research team, led by Suruchi Lata from Boston University, found that malformed lung repair processes in immunocompetent hosts create a conducive environment for the survival and
Tuberculosis
Investigators at the University of Dublin have made a significant breakthrough in the fight against Mycobacterium tuberculosis (Mtb), a type of bacteria that causes tuberculosis (TB). The research, recently published in the journal Scientific Reports, found that dexamethasone, a glucocorticoid hormone, has the potential to inhibit the growth of Mtb
