Genomics
Scientists at Shanghai Ocean University have isolated and characterized a novel bacteriocin, SN-F1, produced by Limosilactobacillus fermentum SN-1, a microorganism found in traditional Qinghai yak yogurt. SN-F1 has been found to exhibit broad-spectrum antimicrobial activity, inhibiting various pathogens and spoilage molds, and demonstrating significant thermostability and stability across a wide
Biochemistry
Researchers at the University of California have shed light on the distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity, detailing new data in Membrane Proteins - G-Protein-Coupled Receptors. The study revealed how the N termini of these chemokines drive receptor pharmacology, with critical residues influencing receptor activation,
Biochemistry
Researchers at the University of Washington have developed a novel approach to designing ion channels, a crucial aspect of biological systems, using a bottom-up method based on RFdiffusion. This breakthrough enables the precise arrangement of amino acid side chains, a feature that native ion channels possess, allowing for selective and
Biochemistry
Researchers at the University of Washington have developed a novel approach to designing ion channels, a crucial aspect of biological systems, using a bottom-up method based on RFdiffusion. This breakthrough enables the precise arrangement of amino acid side chains, a feature that native ion channels possess, allowing for selective and
Biochemistry
Researchers at the University of California have shed light on the distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity, detailing new data in Membrane Proteins - G-Protein-Coupled Receptors. The study revealed how the N termini of these chemokines drive receptor pharmacology, with critical residues influencing receptor activation,
Membrane proteins
Cellular membrane proteins play a vital role in various bodily functions, but understanding their behavior and function is challenging due to their position within the cell's lipid membrane. Scripps Research scientists have now developed a new computer-driven strategy to study these proteins at the atomic level. By designing
Biochemistry
Researchers at the Scripps Research Institute in La Jolla, California, have made significant progress in understanding the behavior of proteins in lipids. They found that protein behavior in lipids is poorly understood and inadequately represented in current computational models. To address this, the researchers designed and predicted bilayer-embedded molecular structures
Biochemistry
Researchers at Zonsen PepLib Biotech Inc. have developed a state-specific peptide design pipeline targeting G protein-coupled receptors (GPCRs), which play critical roles in various physiological processes. The pipeline enables the tailored design of agonists or antagonists based on the active or inactive conformational states of GPCR structures. Using this approach,
Biochemistry
Scientists at the University of Queensland have made a breakthrough discovery in the field of membrane proteins, specifically in the realm of vesicular transport proteins. According to a recent study, the team has proposed a model for membrane curvature generation by caveolin discs driven by differential contact interaction. This research
Biochemistry
Research at Utah Valley University has uncovered a significant link between the evolution of Down Syndrome Cell Adhesion Molecule 1 (DSCAM1) and the development of sociality in insects. The study, published in the journal Insect Systematics and Diversity, reveals that DSCAM1 has undergone accelerated evolution in certain regions of the
Genes
Recent research findings have shed light on the importance of erythroid cells in maintaining a tightly regulated immune environment in mouse placentas. According to a study published in Frontiers in Immunology, erythroid cells comprise a significant proportion of the placental mononuclear cells, expressing genes involved in antigen presentation, immunomodulation, and
Biochemistry
Researchers at Zonsen PepLib Biotech Inc. have developed a state-specific peptide design pipeline targeting G protein-coupled receptors (GPCRs), which play critical roles in various physiological processes. The pipeline enables the tailored design of agonists or antagonists based on the active or inactive conformational states of GPCR structures. Using this approach,
