National Academy of Sciences

National Academy of Sciences

Temperature Adaptation in Lactate Dehydrogenase-A Reveals Convergent Evolution in Key Protein Regions

Research conducted at the Ocean University of China has shed light on the mechanisms underlying temperature adaptation in lactate dehydrogenase-A (LDH-A) enzymes. The study identified specific amino acid substitutions that contribute to the thermal stability of LDH-A, revealing striking convergence in the sites of temperature-adaptive evolution across diverse species. This