Pediatrics

Pediatrics

Bivalirudin Dosage in Neonates and Infants Undergoing Arterial Switch Operation on Integrated Extracorporeal Membrane Oxygenation-Cardiopulmonary Bypass Circuit

Research conducted at the All India Institute of Medical Sciences (AIIMS) has found that the dosage of bivalirudin in neonates and infants undergoing arterial switch operation on integrated extracorporeal membrane oxygenation-cardiopulmonary bypass (CPB) circuit can be effectively determined. The study, published in the Journal of Cardiothoracic and Vascular Anesthesia, aimed

Pediatrics

Multi-Omics Analysis Reveals Therapeutic Vulnerabilities in Pediatric Low-Grade Glioma Models

Researchers from Jena University Hospital, Germany, have conducted a study on the molecular mechanisms of signaling pathways regulating oncogene-induced senescence (OIS) and the senescence-associated secretory phenotype (SASP) in pediatric low-grade gliomas (pLGGs). The study utilized a multi-omics approach to identify key OIS effectors and differentially regulated pathways upon MAPK inhibition.