Pediatrics

Pediatrics

Driver Mutations in Myeloid and Lymphoid Cells Point to Multipotent Progenitor Origin of Diverse Histiocytic Neoplasms

Research at the Princess Maxima Center for Pediatric Oncology has shed new light on the origin of histiocytic neoplasms, rare myeloid diseases characterized by MAPK pathway-activating genetic alterations. The study found that circulating blood cells in patients with histiocytosis lesions carried the same driver mutation, suggesting that multipotent progenitors acquired