Molecular dynamics
Researchers from the Universitat Autonoma de Barcelona have made significant advancements in the field of protein-protein interaction (PPI) modulation. Utilizing AlphaFold2 (AF2) and molecular dynamics (MD) refinements, the team evaluated the performance of AF2 models against experimentally solved structures in docking protocols targeting PPIs. The study demonstrated that AF2 models
Peptides
Research conducted by Sophie Watcham and colleagues at BicycleTx Limited in Cambridge, UK, has led to the discovery of peptide inhibitors that can prevent the activity of the GDF15-GFRaL-RET signaling complex, a key player in various disease states, including cancer and wasting disorders like cachexia. The researchers used a structure-guided
Protein-protein interactions
A team of researchers from Qingdao University has made a significant contribution to the field of genomics by developing a novel deep learning framework, EDG-PPIS, that efficiently predicts protein-protein interaction sites. According to a recent study published in BMC Genomics, the framework addresses existing challenges in protein-protein interaction site prediction
