University of California
Research has identified a novel mechanism of regulating the retinoblastoma protein (pRb), a crucial tumor suppressor, through arginine methylation. This process, mediated by protein arginine methyltransferase 4 (PRMT4), parallels phosphorylation and is essential for pRb's tumor suppressor function. The study reveals that arginine methylation creates a better substrate
Proteins
Research has shown that ExsA, a member of the AraC family of transcriptional regulators, plays a critical role in activating the type III secretion system (T3SS) in Pseudomonas aeruginosa. This process involves the binding of ExsA to specific DNA sequences, a mechanism that is conserved across different bacterial species. However,
Proteins
Researchers from Vanderbilt University have successfully designed and crystallized a small molecule inhibitor of the Replication Protein A (RPA) interaction motif, a critical component of the DNA damage response and repair pathway. This innovation holds promise for the development of cancer treatments that target the upregulation of DNA damage response
