T cells
Regulatory T cells (Tregs) play a crucial role in promoting hair growth and skin regeneration through the activation of hair follicle stem cells. Research conducted by the University of California has revealed the mechanisms driving Treg accumulation in hair follicles, which is essential for hair regeneration. The study found that
T cells
The landscape of cancer treatment is rapidly evolving with the emergence of chimeric antigen receptor (CAR) T-cell therapy, a cutting-edge approach that holds promise for patients with certain types of cancer. Researchers at the City of Hope National Medical Center have highlighted the importance of advanced practice nurses (APNs) in
T cells
Research has shed new light on the genetic factors contributing to pulmonary tuberculosis (PTB) susceptibility in the Thai population, revealing a significant association between CTLA-4 gene polymorphisms, particularly CTLA4+6230A/G, and the risk of PTB. The study, conducted by researchers from Srinakharinwirot University, used polymerase chain reaction-restriction fragment length
Communicable diseases
Research on Mycobacterium infections, specifically tuberculosis (TB), has made significant progress in recent years. A new study published in Microbiology Spectrum has shed light on the role of CD8+ T cells in the host response to TB infection. The study found that the QuantiFERON-TB Gold Plus (QFT-Plus) assay, which replaces
T cells
Researchers from the University of Colorado Anschutz Medical Campus have made a groundbreaking discovery in understanding the mechanisms behind type 1 diabetes. By studying the formation of hybrid insulin peptides (HIPs), they found that a single leucine-to-isoleucine substitution in insulin C-peptide can significantly disrupt HIP formation in NOD mouse islets.
Non-Hodgkin lymphomas
Researchers at the University Hospital of Lyon in France have made a significant discovery regarding the treatment of aggressive B-cell lymphoma using CAR T-cell therapy. A study published in the journal Blood Advances found that patients who experience late failure after CAR T-cell therapy have a poor prognosis, with most
T cells
Virax Biolabs Group Limited, a biotechnology company focused on the detection of immune responses to and diagnosis of viral diseases, has successfully completed patient recruitment for its clinical study evaluating the performance of the ViraxImmune[TM] assay in detecting T cell dysfunction in Post-Acute Infection Syndromes (PAIS). The study, conducted
Non-Hodgkin lymphomas
Researchers at the University Hospital of Lyon in France have made a significant discovery regarding the treatment of aggressive B-cell lymphoma using CAR T-cell therapy. A study published in the journal Blood Advances found that patients who experience late failure after CAR T-cell therapy have a poor prognosis, with most
T cells
A new study published in the Haematologica journal provides four-year follow-up results on the efficacy, safety, and pharmacokinetics of tisagenlecleucel treatment for patients with relapsed/refractory follicular lymphoma. The study, led by researchers from the University Teaching Hospital, demonstrates robust and durable responses with tisagenlecleucel and a favorable safety profile,
T cells
A new study from Kumamoto University School of Medicine in Japan has shed light on the rare occurrence of peripheral T-cell lymphoma following CD19-targeted chimeric antigen receptor T cell therapy. Researchers investigated a case of a 66-year-old male patient who developed peripheral T-cell lymphoma eight months after receiving CD19-directed CAR
T cells
Caribou Biosciences, a clinical-stage CRISPR genome-editing biopharmaceutical company, has announced encouraging clinical data from its phase 1 trial evaluating CB-011, an off-the-shelf anti-BCMA CAR-T cell therapy, in patients with relapsed or refractory multiple myeloma. The results highlight the potential of CB-011 as a best-in-class allogeneic CAR-T cell therapy for this
Medical centers
Researchers at the University of Kansas Medical Center have made a significant discovery in the field of cytokines and intercellular signaling peptides and proteins. Their study, published in the International Journal of Molecular Sciences, reveals that misregulation of C-C chemokine receptor 7 (CCR7) has been linked to multiple autoimmune diseases,
