Antigens
Researchers in Portland, Oregon have made a significant breakthrough in the field of immunology by detailing the role of interferons in regulating MR1 transcription and antigen presentation. According to the study, interferons, such as IFNg, play a crucial role in stimulating MR1 expression and antigen presentation to MAIT cells, a
Antigens
Researchers in Portland, Oregon have made a significant breakthrough in the field of immunology by detailing the role of interferons in regulating MR1 transcription and antigen presentation. According to the study, interferons, such as IFNg, play a crucial role in stimulating MR1 expression and antigen presentation to MAIT cells, a
Medical centers
Researchers at Columbia University Irving Medical Center have made significant findings in the field of Experimental Medicine, demonstrating that lung tissue-resident memory T cells (TRM) play a dual role in protecting against respiratory viral infections. According to the study, published in the Journal of Experimental Medicine, TRM not only augment
Cancer
Recent research conducted by investigators at the University of Texas MD Anderson Cancer Center has shed new light on the role of germline genetic aberrations in predicting toxicity and efficacy in patients with large B-cell lymphoma treated with chimeric antigen receptor T-cell therapy (CART). The study, published in the Journal
Cancer
Researchers at the University of Porto have conducted a study on the pharmacokinetics of anti-PD-1 antibodies, such as nivolumab, pembrolizumab, and cemiplimab, and explored their pharmacokinetic-pharmacodynamic relationships. The study highlights the importance of baseline clearance and its reduction during therapy as dynamic biomarkers for guiding individualized dosing strategies. The researchers
Cancer
Scientists at the University of Texas Southwestern Medical Center have shed new light on the mechanisms of cancer immunotherapy by mapping the clonal expansion and differentiation of neoantigen-specific CD8+ T cells in the tumor and draining lymph node in mouse prostate cancer. The research, published in Cancer Immunology Research, reveals
Cancer
Researchers from the University of California have developed a new model system to perform genome-wide in vivo CRISPR screens to identify genetic modifiers of T cell activity in the tumor microenvironment. In a groundbreaking study, the team conducted two genome-wide CRISPR knockout screens to identify genes regulating T cell intratumoral
Medical centers
Cancer vaccines, once deemed ineffective as standalone therapies, are now being explored as complementary treatments to immunotherapy, which has revolutionized cancer care but still poses challenges in achieving durable efficacy. Researchers at Georgetown University Medical Center have summarized the current understanding of the immunobiology of T cell priming in cancer,
Medical centers
Researchers from Erasmus University Medical Center Cancer Institute have shed light on the role of tumor-associated macrophages (TAMs) in suppressing T cell responses in solid tumors. According to the study, TAMs can be converted from immune-supportive to immune-suppressive cells, facilitating tumor evasion from T cell control. This perspective highlights the
Medical centers
Researchers at the University of Nebraska Medical Center have made significant discoveries regarding HIV-1 infection in the brain, specifically focusing on the role of mononuclear leukocytes. Their study, published in the Journal of Neuroinflammation, reveals that certain types of T cells play a crucial role in initiating SIV entry into
Endometriosis
A groundbreaking study from West China Second University Hospital in Chengdu, Sichuan, has shed new light on the complex mechanisms underlying endometriosis, a chronic and often debilitating gynecological disorder that affects millions of women worldwide. Researchers, led by Yuchan Zhong, have discovered that CD8+ tissue-resident memory T cells (CD8+TRM)
Cancer
Researchers from the Icahn School of Medicine at Mount Sinai published a study evaluating 213 patients with myeloma treated with B-cell maturation antigen-directed CAR-T cells. The study found that prolonged hematologic toxicity remains a common adverse event, and secondary myeloid malignancies are a significant safety concern. The research also revealed
