Cancer
Apollo Cancer Centre (ACC) in Navi Mumbai has successfully treated two patients with made-in-India CAR T-cell therapy, marking a significant milestone in the hospital's commitment to delivering high-quality, life-saving transplant services. The centre has seen remarkable success with 85 Bone Marrow Transplant (BMT) procedures, with a long-term success
Cancer
Research has shown that human papillomavirus type 16 (HPV16) positive cancers create a tumor environment that induces antigen-presenting cells to increase IL-23 expression. This cytokine impacts the antitumor cytotoxic T-cell response in HPV16+ cancer. The American Association of Immunologists Careers in Immunology and Nih have provided financial support for this
Cancer
Researchers at Sichuan University have made a significant breakthrough in cancer immunotherapy, developing a novel platform that synergistically suppresses cancer cell stemness. According to the study, cancer cells with stemness characteristics can evade immune recognition and killing, leading to recurrence and metastasis. To overcome this, the researchers created salinomycin-repurposed endoplasmic
Cancer
Researchers from Sichuan University have made a significant discovery in the field of cancer therapy, identifying a new strategy to target B7-H3, an immune-checkpoint molecule overexpressed in several cancer types. The study, published in International Immunopharmacology, found that natural killer (NK) cells, another important part of the cellular immune system,
Cancer
UCLA scientists have made a groundbreaking discovery in cancer treatment, successfully reprogramming a patient's blood-forming stem cells to generate a continuous supply of functional T cells, the immune system's most powerful cancer-killing agents. This approach offers a new way to deliver immunotherapy, providing a longer-lasting defense
Cancer
A team of researchers at the University of Chicago has developed a novel "universal" chimeric antigen receptor (CAR) platform that addresses the limitations of traditional CAR-T cell therapy by providing enhanced safety, adaptability, and the potential to overcome long-standing barriers in cancer immunotherapy. The new platform, called GA1CAR,
Cancer research
Scientists at the Ludwig Institute for Cancer Research have made a significant discovery in the field of cancer vaccines. Their research, published in Immunology & Cell Biology, reveals that the adsorption of antigens to polymeric nanoparticles can significantly enhance cytotoxic T-cell responses and anti-tumor immunity. This breakthrough has far-reaching implications
Cancer research
Researchers at the National Cancer Institute (NCI) have discovered that high levels of endogenous Omega-3 fatty acids can significantly improve the efficacy of dendritic cell-based cancer vaccines in mice. According to a recent study published in Cancer Immunology Research, the presence of Omega-3 fatty acids enhances dendritic cell antigen presentation,
Cancer research
Research at Chiba University in Japan has identified the PI3K/Akt signaling pathway as a key regulator of CD155 expression, which contributes to resistance to cancer immunotherapy, particularly in tumors with an inflamed tumor microenvironment. The study found that inhibition of Dyrk1A, a key regulator of CD155 expression, or treatment
Cancer
Investigators at Peking University Cancer Hospital and Institute have made a significant breakthrough in the development of engineered T-cells to target Epstein-Barr virus (EBV)-associated malignancies. According to a new report, the researchers have successfully identified and isolated Epstein-Barr virus nuclear antigen 1 (EBNA1)-specific T-cell receptors, which can be
Cancer
Researchers at the University of Turku, Finland, have shed light on the role of Clever-1 in cancer immunosuppression. A recent study published in Theranostics found that Clever-1, a multifunctional scavenger receptor, promotes immunosuppressive activity in macrophages, contributing to tumor immune evasion. The study also identified secreted Clever-1 (sClever-1) as a
Cancer
Researchers at Kunming Medical University have made a significant discovery in the field of cancer immunotherapy, developing an integrated system for screening tumor-specific T-cell receptors (TCRs). According to the study, published in the Journal for ImmunoTherapy of Cancer, the system enables the rapid assembly and construction of TCR libraries, significantly
