University of California
Research has identified a novel mechanism of regulating the retinoblastoma protein (pRb), a crucial tumor suppressor, through arginine methylation. This process, mediated by protein arginine methyltransferase 4 (PRMT4), parallels phosphorylation and is essential for pRb's tumor suppressor function. The study reveals that arginine methylation creates a better substrate
University of California
Researchers have made significant progress in developing site-specific gene addition for gene therapy, a method that can allow stable transgene expression without the need for promiscuously integrating vectors. This approach holds promise for safe and efficacious targeting, particularly in cases where on-target and off-target effects are a concern. In a
University of California
Research on cytometry has led to a discovery that the human c2orf40 gene encodes a tumor suppressor gene called esophageal cancer-related gene-4 (ECRG4), which interacts with the innate immunity receptor complex. According to a study published in Inflammation Research, ECRG4 has pro- and anti-inflammatory activities that depend on cell surface
Universities and colleges
Researchers in Los Angeles, California conducted a study to characterize the interaction between procoagulant and/or anticoagulant serine proteases and human monoclonal IgG antiphospholipid antibodies (aPL) and polyclonal IgG derived from patients with the antiphospholipid syndrome (APS). The study found that sequence changes in human aPL are important in determining
Universities and colleges
Researchers at the University of California, Irvine, have shed light on the mechanisms by which non-acute retroviruses cause cancer. Through their studies, they have discovered new proto-oncogenes and elucidated the cooperation between different proto-oncogenes in tumor development. The researchers also highlighted the risk of insertional activation in gene therapy trials
Universities and colleges
Gene therapy is a highly promising approach for treating a range of diseases, including tissue regeneration and cancer. However, delivering DNA and small interfering RNAs (siRNAs) to disease sites has proven a significant challenge. Researchers at the University of California, Los Angeles, have now developed a new method for loading
Universities and colleges
The American Association of Colleges of Pharmacy (AACP) Student Community Engaged Service Award has selected four outstanding student-led community engagement programs that have been proven to expand access to affordable healthcare and dramatically improve public health. This year's winners include the University of Arkansas for Medical Sciences, University
Universities and colleges
The American Association of Colleges of Pharmacy (AACP) Student Community Engaged Service Award has selected four outstanding student-led community engagement programs that have been delivering consumer education about medication use, expanding access to affordable healthcare, and improving public health. The programs from the University of Arkansas for Medical Sciences, University
Universities and colleges
Researchers from the University of California have identified a potential mechanism for mesenchymal stem cells to promote tissue repair by secreting soluble growth factors. To further enhance this process, the authors suggest combining cell and gene therapies, allowing mesenchymal stem cells to be genetically modified to express higher levels of
Universities and colleges
D.P. Liu and colleagues at the University of California have made a significant breakthrough in cancer therapy research by identifying fatty acids as specific inhibitors of the proto-oncogenic protein Shp2. Through a bioguided isolation process, the researchers isolated 13 compounds from the root of Angelica dahurica, including 10 fatty
Universities and colleges
Scientists at the University of California have developed a method for bulk synthesizing silicon nanowires on millimeter-scale Al2O3 spheres, enabling the production of high-quality nanowires for energy storage applications. This breakthrough, reported in the journal ACS Nano, leverages the vapor-liquid-solid growth mechanism to produce both single-crystalline and crystalline core/amorphous
Universities and colleges
Researchers at the University of California have discovered that conventional clinical and pathologic risk factors in stage II colon cancer provide limited prognostic information and fail to predict response to adjuvant 5-fluorouracil-based chemotherapy. This gap in knowledge has led to the need for new prognostic and predictive biomarkers to identify
