TRAIL Gene Polymorphisms Linked to Gastric Cancer in Chinese Han Population

Strategic Insights -

Gastric cancer, a leading cause of cancer deaths worldwide, has been a focus of research in recent years. A recent study conducted in central China investigated the association between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene polymorphisms and gastric cancer in the Chinese Han population. The study, published in Pharmaceutical Research, found a significant correlation between TRAIL G1525A and C1595T gene polymorphisms and the susceptibility to gastric cancer.

Key Takeaways:

  • The study, conducted in central China, involved 304 patients with gastric cancer and 421 unrelated healthy controls.
  • The research found that the frequency of the genotype carriers of TRAIL 1525A (GA + AA) and 1595T (CT + TT) was significantly lower in gastric cancer patients than in healthy controls (37.2% vs. 61.5%, p < 0.01).
  • The study concluded that TRAIL G1525A and C1595T gene polymorphisms were significantly correlated with the susceptibility to gastric cancer in the Chinese Han population.
  • The researchers, led by C. Wang from the University School of Medicine, highlight the potential role of TRAIL gene polymorphisms in gastric cancer development and progression.
  • The study's findings suggest that genetic testing for TRAIL gene polymorphisms may be a useful tool for identifying individuals at high risk of gastric cancer.

Statistics:

  • 304 patients with gastric cancer were included in the study.
  • 421 unrelated healthy controls were included in the study.
  • The frequency of the genotype carriers of TRAIL 1525A (GA + AA) was 37.2% in gastric cancer patients and 61.5% in healthy controls (p < 0.01).
  • The frequency of the genotype carriers of C1595T (CT + TT) was also significantly lower in gastric cancer patients than in healthy controls (p < 0.01).

Sources:

  • Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China. Pharmaceutical Research, 2015; 32(3): 762-8.
  • Pharmaceutical Research can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.
  • C. Wang et al. (2015). Tumor Necrosis Factor-Related Apoptosis Inducing Ligand Gene Polymorphisms Are Correlated with Gastric Cancer in Central China. Pharmaceutical Research, 32(3), 762-768. doi: 10.1007/s11095-014-1553-1