Triglyceride-Glucose Index as Novel Biomarker for Mild Cognitive Impairment in Patients with Coronary Artery Disease

Strategic Insights -

A recent study published in Biomarkers in Medicine has identified the triglyceride-glucose (TyG) index as a novel biomarker for mild cognitive impairment in patients with coronary artery disease (CAD). The study, conducted by a team of researchers from Capital Medical University, included 1163 patients with CAD who underwent cognitive function assessment. The researchers found a significant negative correlation between the TyG index and Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores, indicating that elevated TyG index values are associated with an increased risk of mild cognitive impairment (MCI).

Key Takeaways:

  • The study investigated the association between the TyG index and cognitive function in patients with CAD, and found a significant negative correlation between the two.
  • The TyG index was independently associated with cognitive function in patients with CAD, with elevated values associated with an increased risk of MCI.
  • The study included 1163 patients with CAD who underwent cognitive function assessment, and used multiple regression analyses to evaluate the relationship between the TyG index and cognitive function.
  • The researchers conducted receiver operating characteristic (ROC) curve analysis to determine the discriminatory ability of the TyG index in identifying patients with MCI.
  • The study suggests that the TyG index may be a useful noninvasive biomarker for identifying high-risk individuals in the CAD population.

Statistics:

  • 1163 patients with CAD were included in the study.
  • The TyG index was negatively correlated with MMSE and MoCA scores (r = -0.16).
  • The study found that elevated TyG index values were associated with an increased risk of MCI.
  • The ROC curve analysis showed that the TyG index had a high discriminatory ability in identifying patients with MCI (area under the curve = 0.85).

Sources:

  • Biomarkers in Medicine
  • Triglyceride-glucose index as a novel biomarker for mild cognitive impairment in patients with coronary artery disease. Biomarkers in Medicine, 2025:1-8.
  • Capital Medical University
  • Jianan Li, Dept. of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China
  • Taylor & Francis Ltd, 2-4 Park Square, Milton Park, Abingdon OR14 4RN, Oxon, England
  • NewsRx. New Heart Disease Study Findings Have Been Reported from Capital Medical University (Triglyceride-glucose index as a novel biomarker for mild cognitive impairment in patients with coronary artery disease). Cardiovascular Week. October 20, 2025; p 89.