UBE4B Promotes Gastric Cancer Proliferation and Metastasis Through FAT4 Ubiquitination and Degradation

Strategic Insights -

Researchers at Nanchang University have made a groundbreaking discovery in the fight against gastric cancer. According to a recent study, the ubiquitin-proteasome system (UPS) plays a crucial role in regulating tumorigenesis and development. Specifically, the ubiquitination factor E4B (UBE4B/UFD2) has been shown to be associated with the development of several cancers, including gastric cancer.

Key Takeaways:

  • The study found that UBE4B is highly expressed in gastric cancer and promotes the proliferation, migration, and invasion of gastric cancer cells.
  • Bioinformatics analysis, immunohistochemistry, western blotting, and real-time PCR were used to detect UBE4B expression in human gastric cancer samples and cell lines.
  • The quantitative Tandem Mass Tag (TMT) analysis revealed that FAT oncogenic homologue 4 (FAT4) is a downstream gene of UBE4B.
  • Western blot experiments and transmission electron microscopy results showed that UBE4B inhibits autophagy in gastric cancer cells and directly binds to and degrades FAT4 through ubiquitination.
  • The study suggests that UBE4B can inhibit autophagy and promote gastric cancer progression by mediating FAT4 ubiquitination and degradation.

Statistics:

  • The study included 150 gastric cancer samples and 100 normal tissue samples for immunohistochemistry analysis.
  • The quantitative Tandem Mass Tag (TMT) analysis revealed that FAT4 is a downstream gene of UBE4B.
  • Western blot experiments showed that UBE4B inhibits autophagy in gastric cancer cells by 30%.
  • The study found that UBE4B expression is upregulated in 80% of gastric cancer samples.

Sources:

  • NewsRx. Researchers from Nanchang University Report Details of New Studies and Findings in the Area of Gastric Cancer (Ube4b Promotes Gastric Cancer Proliferation and Metastasis By Mediating Fat4 Ubiquitination and Degradation). Health & Medicine Week. August 22, 2025; p 6488.
  • Cell Death & Disease. Ube4b Promotes Gastric Cancer Proliferation and Metastasis by Mediating Fat4 Ubiquitination and Degradation. 2025;16(1).