Ventilator-Associated Pneumonia Study Uncovers New Risk Factors

Strategic Insights -

A recent study on ventilator-associated pneumonia (VAP) has shed light on the risk factors associated with outcomes in patients infected with Acinetobacter baumannii, a nosocomial pathogen commonly linked with VAP. The study, conducted at Dr. Moewardi General Hospital in Surakarta, Indonesia, identified moderate-severe comorbidities and malnutrition as significant risk factors for mortality, while prolonged ventilator use was associated with prolonged hospitalization.

Key Takeaways:

  • The study included 80 patients with VAP caused by A. baumannii, with most patients under 60 years old (52.5%) and having good nutritional status (75%).
  • Moderate-severe comorbidities (p=0.001) and malnutrition (p=0.005) were significantly associated with increased mortality.
  • Ventilator use for more than 10 days was significantly associated with increased length of stay (LOS) in the hospital.
  • The study suggests that identifying these risk factors can help medical personnel manage conditions that worsen VAP outcomes and reduce the risk of A. baumannii-related mortality.
  • The research was conducted at Dr. Moewarti General Hospital, Surakarta, and included data from patient medical records.
  • The study's findings were published in the Jurnal Respirasi journal, volume 11, issue 3, pages 201-207, in 2025.

Statistics:

  • 80 patients were included in the study.
  • 52.5% of patients were under 60 years old.
  • 75% of patients had good nutritional status.
  • 63.75% of patients were on ventilators for less than 10 days.
  • 51.25% of patients had mild comorbidities.
  • Moderate-severe comorbidities were associated with a significant increase in mortality (p=0.001).
  • Malnutrition was significantly associated with increased mortality (p=0.005).
  • Ventilator use for more than 10 days was associated with a significant increase in LOS (p According to the study.

Sources:

  • Factors Associated with Outcomes of Acinetobacter baumannii Infection in Ventilator-Associated Pneumonia in the ICU of Dr. Moewarti General Hospital, Surakarta. Jurnal Respirasi, 2025, 11(3):201-207. (https://doi.org/10.20473/jr.v11-I.3.2025.201-207)
  • Lutfi Lafil Cahya Putra, et al. Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.