Proteins
Breakthrough in Protein Manipulation: New Peptide-Based Systems for Rapid and Reversible Knock-Down
Researchers from the University of British Columbia have developed a groundbreaking peptide-based system for rapidly and reversibly knocking down non-genetically modified native proteins. This innovative approach harnesses the endogenous lysosome-dependent autophagy system, chaperone-mediated autophagy (CMA), to selectively degrade target proteins. The system consists of a peptide comprising a CMA-targeting signal