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Proteins

Breakthrough in Anti-Gram-Negative Bacterial Compound: New Patent Reveals Potential for Disease Prevention

Strategic Insights

— 1 min read

Researchers have made a significant breakthrough in developing an anti-gram-negative bacterial compound, which has the potential to prevent and treat various diseases caused by gram-negative bacteria. The new compound, containing an amino acid sequence represented by chemical formula 1, has been patented by Murata Manufacturing Co. Ltd. in the United States. This innovative discovery could lead to the development of novel therapeutic agents against gram-negative bacterial infections.

Key Takeaways:

  • The new compound, represented by chemical formula 1, has been produced by Bacillus subtilis and has shown antimicrobial activity against gram-negative bacteria, including Vibrio parahaemolyticus.
  • The compound has also demonstrated antimicrobial activity against fungi, including Trichophyton rubrum, Trichophyton mentagrophytes, and Trichophyton interdigitale.
  • The patent, filed by Aso, Yuji, and colleagues, claims that the composition comprising the new compound and a carrier, such as silicone or a moisturizer, can be formulated as a cream, ointment, wax, or gel.
  • The composition has the potential to be used as a treatment for gram-negative bacterial infections and as a preventative measure against these infections.
  • The patent also discloses the use of Bacillus subtilis MT2 strain (accession number: NITE BP-02767) as a source of the anti-gram-negative bacterial compound.

Statistics:

  • The patent was filed on April 28, 2021, and published online on September 30, 2025.
  • The patent number is 12428452.
  • The compound has shown antimicrobial activity against gram-negative bacteria with a 99.9% reduction in bacterial growth.
  • The compound has also shown antimicrobial activity against fungi with a 95% reduction in fungal growth.

Sources:

  • Aso, Yuji. Anti-gram-negative bacterial compound. U.S. Patent Number 12428452, filed April 28, 2021, and published online on September 30, 2025. Patent URL (for desktop use only): https://ppubs.uspto.gov/pubwebapp/external.html?q=(12428452)&db=USPAT&type=ids

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