Cancer research
A new case report published in the Journal of Hematology & Oncology has highlighted the potential of FOLFOX4 therapy as a salvage treatment for patients with advanced urothelial cancer who are refractory to gemcitabine. The study, conducted by researchers from Soonchunhyang University, reported a complete response to FOLFOX4 therapy in
Cancer treatment
Lung cancer is a leading cause of cancer-related deaths worldwide, with most patients presenting with advanced disease and limited treatment options. Targeted therapies, such as erlotinib and gefitinib, have shown promise in inhibiting the epidermal growth factor receptor (EGFR) pathway, but only a fraction of patients respond to these agents,
Cancer research
Cancer researchers have discovered that Interleukin-10 (IL-10) expression in lung tumor cells increases their resistance to apoptosis and metastatic potential, leading to a reduced success rate in non-small cell lung carcinoma (NSCLC) treatment. The study, published in Cytokine, aimed to evaluate the effects of tumor-derived IL-10 on lung cancer cells
Cancer treatment
Researchers in Singapore have made a significant breakthrough in cancer therapy by developing a novel approach that combines tissue-specific promoter and microRNA regulation to control the expression of a suicide gene in cancer cells. This study, published in Molecular Therapy, demonstrates the potential of this method to selectively target and
Cancer treatment
A recent study published in Nutrition Reviews suggests that a nutritional approach may play a beneficial role in skin cancer prevention. Researchers from Tel Aviv University found that nutrients such as antioxidant vitamins, minerals, and phytochemicals, in addition to n-3 polyunsaturated fatty acids, n-9 monounsaturated fatty acids, and low pro-inflammatory
Cancer treatment
Prostate cancer cells with defective Kelch-like ECH-associated protein 1 (Keap1) function exhibit increased resistance to chemotherapy and radiation, enabling tumor growth and proliferation. Research led by P. Zhang and colleagues at the Johns Hopkins University's Sidney Kimmel Comprehensive Cancer Center has shed light on the mechanisms underlying this
Cancer treatment
Researchers in the United States, led by C. Eng of the University of Texas M.D. Anderson Cancer Center, have published a new report on the evolving role of monoclonal antibodies in treating colorectal cancer. The study highlights the critical impact of molecular markers on the effectiveness of targeted biologic
Cancer treatment
Researchers in Seoul, Korea have discovered that a novel Cdk inhibitor, xylocydine, is an effective inducer of apoptosis in hepatocellular carcinoma (HCC) cells in vitro and in vivo. The study, published in Cancer Letters, demonstrates that xylocydine selectively down-regulates the activity of Cdk1 and Cdk2, leading to significant cell growth
Cancer treatment
Researchers at Wayne State University have made significant discoveries about the role of telomeres and telomerase in cancer drug resistance. Their study, published in the Journal of Chemotherapy, found that changes in telomerase activity and/or telomere length are key factors in the development of resistance to cancer drugs. The
Cancer treatment
Scientists in Hangzhou, People's Republic of China, have reported promising results from a study combining oncolytic adenovirus ZD55 with therapeutic gene IL-24, leading to enhanced antitumor effects in lung cancer. The researchers found that the combination of ZD55-IL-24 with chemotherapy agents, such as adriamycin (ADM) or cisplatin (DDP)
Cancer
Live biologics, a novel class of cancer therapies derived from viruses, may offer a new hope for patients with hard-to-treat cancers. Calgary-based Oncolytics Biotech Inc. has developed a live cancer biologic called REOLYSIN[R], which targets cancer cells with an activated Ras pathway, a characteristic found in approximately two-thirds of
Cancer
Cationic defence peptides, a type of antimicrobial and anticancer agent, have been shown to have therapeutic potential. However, the role of C-terminal amidation in their efficacy has been unclear. A study by Dennison and colleagues analyzed the toxicity of these peptides to normal fibroblast cells, various tumour cells, and bacterial
