Apoptosis
Researchers have made significant progress in understanding the immunogenicity of tislelizumab, a humanized anti-PD-1 antibody, which has been analyzed in a comprehensive study involving 3815 patients. The investigation focused on the incidence of anti-drug antibodies (ADAs) and the feasibility of assessing the suitability of validation cut points (VCPs) using statistical
Biological products
Lava Therapeutics N.V. has been issued a patent for a novel antibody that targets prostate-specific membrane antigen (PSMA) and can stimulate autologous Vg9Vd2 T cells to kill prostate cancer cells. The patent, titled "Antibodies that bind PSMA and gamma-delta T cell receptors," was filed on May 6,
Biological products
Research from the Technical University in Germany has demonstrated the efficient manufacturing of complex biopharmaceuticals using innovative downstream processing strategies, specifically membrane chromatography. This approach enables high-throughput separations at elevated flow rates, offering a promising alternative to resin-based systems. The study focuses on the Natrix CH membrane, a novel mixed-mode
Biological products
A new study from the Faculty of Pharmaceutical Sciences has uncovered a potential solution to managing Aedes aegypti mosquitoes, which are carriers of infectious diseases that affect millions of people worldwide. The research explored the effectiveness of using Persea americana plant extracts to eradicate the vector, with significant larvicidal effects
Biological products
Turmeric, a plant with antibacterial properties due to its curcumin content, has been found to inhibit E. coli growth in a study conducted by researchers at Universitas Jember. The investigation examined the effect of various factors on the antibacterial activity of turmeric rhizome ethanol extract, including the type of ethanol
Biological products
Researchers at the Massachusetts Institute of Technology have developed a new imaging probe called ChERT, which allows for the detection of cholinesterase (ChE) activity in the brain and peripheral regions using magnetic resonance imaging (MRI). This breakthrough could be crucial for studying the basic biology of cholinergic systems and disorders
Biological products
A team of researchers at the Massachusetts Institute of Technology has successfully developed a low-cost, open-source bioreactor platform for cultivating Synechocystis sp. PCC 6803, a photosynthetic microbe with high potential for capturing excessive atmospheric carbon while generating valuable bioproducts. The bioreactor platform, which incorporates a photobioreactor, a lysis module, and
Biological products
Researchers from the Indian Institute of Technology (IIT) Patna have developed a new method for separating monoclonal antibodies from acidic charge variants using physics-informed neural networks (PINN). The method uses a combination of the Yamamoto model and Møllerup's thermodynamic approach to predict the distribution coefficient of monoclonal antibodies
Biological products
Recent breakthroughs in developing anti-CD19 antibodies and multi-specific binding proteins are gaining momentum in the fight against cancer. Researchers from Cullinan Therapeutics Inc. have filed a patent for a groundbreaking invention that combines the potency of BiTE constructs with the convenience of longer-lasting treatments. The new antibodies and proteins have
Antineoplastic agents
A new analysis conducted by Komodo Health and the Tigerlily Foundation, a national breast cancer patient advocacy organization, reveals significant progress in the adoption of antibody-drug conjugate (ADC) treatment in metastatic breast cancer. The study confirms growing clinical acceptance of this innovative therapy but also highlights persistent inequities in access
Biological products
Valink Therapeutics Inc. has closed a significant funding round to accelerate the development of its novel therapeutics for improving cancer treatment outcomes. The company's proprietary bispecific antibody-drug conjugates (bsADCs) technology aims to address key limitations of current ADCs by integrating novel targeting strategies with improved payload delivery. The
Biological products
Researchers at Crystal Bioscience Inc. have developed a transgenic chicken that produces antibodies with long CDR3 regions, a significant breakthrough in the field of immunology. The chicken's genome has been engineered to include functional immunoglobulin heavy chain genes, which encode for antibodies with long CDR3 regions. This innovation
