Cancer
Research has made a significant breakthrough in the field of cancer gene therapy with the development of a cyclodextrin-based drug delivery system. This novel approach has the potential to overcome the limitations of existing oncotherapies, which are often hindered by low solubility and poor bioavailability. The study, published in the
Cancer
Researchers at Memorial Sloan-Kettering Cancer Center have made a significant discovery in the field of gene therapy. By investigating the anti-tumor response in the leptomeninges, a cerebrospinal fluid-filled space surrounding the brain and spinal cord, the team has identified a unique role for interferon-g (IFN-g) in controlling cancer cell growth.
Cancer
Researchers from the University of Primorska have developed a novel bacteriophage-based vaccine strategy that has shown significant efficacy in treating aggressive melanoma in mice. The study, published in Scientific Reports, evaluated the antitumor efficacy of the bacteriophage vaccine alone and in combination with gene electrotransfer (GET) of interleukin-12 (IL-12) plasmids.
Cancer
Researchers at Sharda University in Uttar Pradesh, India, have been studying the potential of zein nanoparticles (ZNPs) as a biocompatible and biodegradable nanocarrier system for brain-targeted drug delivery. According to their review, ZNPs have the ability to encapsulate hydrophobic drugs and undergo surface modifications that enable effective penetration of the
Cancer research
Scientists at the University of Hong Kong have made a significant discovery in the fight against liver cancer, identifying new targets that can enhance the effectiveness of lenvatinib, a commonly used treatment for the disease. According to a recent study published in the journal Cellular and Molecular Gastroenterology and Hepatology,
Cancer research
A new study published in npj Precision Oncology has shed light on the incidence of germline pathogenic variants in DNA repair pathways in patients with translocation-associated sarcomas (TAS). The research, conducted by a team of scientists at the Memorial Sloan-Kettering Cancer Center, aimed to investigate the clinical impact of germline
Cancer research
Researchers from the Beijing Institute of Pharmacology and Toxicology have made a significant discovery in the field of cancer gene therapy. According to their study, published in Nature Communications, lipid nanoparticles carrying mRNA encoding a viral 3 C protease can efficiently suppress tumors by selectively inducing tumor cell apoptosis. This
Cancer
Kara Tointon, a British actress known for her roles in EastEnders and Strictly Come Dancing, has spoken out about undergoing a double mastectomy after discovering she carried the BRCA gene. The soap star, 41, made the decision to have the preventative surgery after her mother's death from ovarian
Cancer research
Scientists at China Three Gorges University have made a significant breakthrough in lung cancer research, unveiling new molecular markers and a prognostic signature that could improve immunotherapy responses and clinical outcomes in patients with lung adenocarcinoma. According to the study published in PeerJ, the researchers identified 10 machine learning algorithms
Cancer
Kara Tointon, a well-known actress from the soap opera EastEnders, has spoken publicly about her decision to undergo a double mastectomy after discovering she carried the BRCA1 gene, which puts her at a high risk of developing cancer. Working with the gynaecological cancer charity the Eve Appeal, Tointon shared her
Cancer
Researchers from Jinan University have discovered that the RNA methyltransferase METTL1 is highly expressed in various types of tumors and is associated with poor prognosis and immune infiltration. The study published in the Guangxi Yike Daxue xuebao journal found that METTL1 expression was significantly higher in cancer tissues compared to
Cancer
Researchers from the National Cancer Institute (NCI) have highlighted the critical role of biobanks in genetic research, particularly in genome-wide association studies (GWAS) and the integration of multi-omics data. According to a recent study published in Human Molecular Genetics, biobanks have driven transformative insights into the genetic basis of complex
