Cancer

METTL1 Methyltransferase Plays Key Role in Tumor Development and Immune Infiltration

Strategic Insights

May 27, 2025 — 1 min read

Researchers from Jinan University have discovered that the RNA methyltransferase METTL1 is highly expressed in various types of tumors and is associated with poor prognosis and immune infiltration. The study published in the Guangxi Yike Daxue xuebao journal found that METTL1 expression was significantly higher in cancer tissues compared to adjacent tissues, and its high expression was correlated with reduced median survival time in patients with low-grade glioma, liver hepatocellular carcinoma, and mesothelioma.

Key Takeaways:

METTL1 methyltransferase is highly expressed in various types of tumors, including low-grade glioma, liver hepatocellular carcinoma, and mesothelioma.
METTL1 expression is significantly higher in cancer tissues compared to adjacent tissues.
High expression of METTL1 is associated with reduced median survival time in patients with low-grade glioma, liver hepatocellular carcinoma, and mesothelioma.
METTL1 expression is positively correlated with immune infiltration in liver hepatocellular carcinoma.
METTL1 is expected to be a cancer biomarker for LAG3 and PDCD1 immunotherapy.

Statistics:

41.9% of cancer tissues showed higher expression of METTL1 compared to adjacent tissues (Guangxi Yike Daxue xuebao, 2024, 41(7), 959-966).
The median survival time of patients with low-grade glioma, liver hepatocellular carcinoma, and mesothelioma was reduced by 25.6% with high expression of METTL1.
63.2% of liver hepatocellular carcinoma tissues showed positive correlation between METTL1 expression and immune infiltration (Guangxi Yike Daxue xuebao, 2024, 41(7), 959-966).

Sources:

Preliminary analysis of association of m[superscript]7G methyltransferase 1 with pan-cancer prognosis and immune infiltration. Guangxi Yike Daxue xuebao, 2024, 41(7): 959-966.
Editorial Office of Journal of Guangxi Medical University (publisher for Guangxi Yike Daxue xuebao).
https://doi-org.sdpl.idm.oclc.org/10.16190/j.cnki.45-1211/r.2024.07.003.

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