Genetic research
New research has shed light on the potential use of cell-free DNA (cfDNA) methylation profiles to predict outcomes in non-small cell lung cancer (NSCLC) patients treated with afatinib. The study, conducted at Keio University School of Medicine, analyzed the cfDNA methylation profiles of 103 patients with NSCLC and found that
Genetic research
Researchers at the University of Salento, in collaboration with Universita Cattolica del Sacro Cuore, have conducted an exploratory study to investigate the relationship between circulating cell-free mitochondrial DNA (ccf-mtDNA) and inflammation in older adults with pancreatic cancer. The study analyzed plasma/serum samples from 14 participants, including 3 healthy controls
Genetic research
The Cyprus Institute of Neurology and Genetics (CING) has initiated two new research projects, BcRAVE and OVATION, aimed at enhancing the classification of genetic variants linked to breast and ovarian cancer. These projects, with a combined funding of £329,000, will run for two years under the EU-backed Cohesion Policy
Genetic research
Researchers at the University of Alaska Anchorage have made a significant contribution to the field of cancer gene therapy with their new study on C3-liposome delivery of MUC1 peptide and TLR agonists. The study, published in the journal Pharmaceutics, demonstrates the potential of this approach to enhance anti-tumor immunity and
Cancer research
Researchers from Fudan University have developed a novel micro-nano liposome system, PCAL@TM, which has shown significant improvements in the treatment of lung cancer. The system targets the delivery of a chemotherapy drug, paclitaxel (PTX), directly to the tumor site, while also releasing oxygen to enhance the effectiveness of the
Cancer research
Researchers from the University of Coimbra have developed a novel nanocarrier system that combines chemotherapeutic agents and nucleic acids to target liver cancer cells. Their study, published in the International Journal of Pharmaceutics, demonstrates the potential of this mesoporous silica-glycopolymer hybrid nanoplatform in dual-targeted therapy for liver cancer. This innovative
Cancer research
Researchers from Macau University of Science and Technology have made a significant discovery in the field of cancer gene therapy, developing a new treatment for prostate cancer that combines chemotherapy and photodynamic therapy. The therapeutic effect of chemotherapy on prostate cancer has been limited, but this innovative approach addresses this
Cancer research
Research conducted at the "Grigore T. Popa" University of Medicine and Pharmacy in Iasi, Romania, has made significant advancements in cancer gene therapy. Despite the limitations of conventional therapy, including low water solubility, bioavailability, and high dose-dependent toxicity, scientists have developed new delivery methods for antineoplastic drugs. By
Genetic research
A new prospective multicenter study by researchers at the Mayo Clinic has found that combining pancreatic juice (PJ) and plasma carbohydrate antigen 19-9 (CA 19-9) biomarkers can enhance diagnostic sensitivity and improve early detection of pancreatic ductal adenocarcinoma (PDAC). The study, published in Clinical Gastroenterology and Hepatology, evaluated the sensitivity
Cancer research
Researchers at the University of Cambridge have found that personalized risk assessment (PRA) for women with or without germline pathogenic variants (GPVs) in breast and ovarian cancer susceptibility genes can be cost-effective in some situations. The study compared conventional risk assessment (CRA) with PRA, which takes into account genetic and
Cancer genetics
The Bombay high court has issued a notice to the Central Drugs Standard Control Organisation (CDSCO) to respond to a petition filed by Datar Cancer Genetics Pvt Ltd, a Nashik-based cancer research company seeking permission to conduct phase one human trials of its cancer immunotherapy drug, Per-C-Vax. The company claims
Cancer research
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for more than 80% of all lung cancer cases worldwide. Unfortunately, most patients are diagnosed with NSCLC at an advanced stage, making treatment challenging. Recent studies have shown that cell-free circulating tumor DNA (ctDNA) in plasma
