Cancer metastasis
Research conducted by Jian Wang and colleagues has shed new light on the mechanisms underlying lung cancer metastasis. The study, published in the International Journal of Oncology, highlights the crucial role of exosomal microRNAs in promoting metastasis and explores their potential as diagnostic indicators and therapeutic targets. Lung cancer is
Cancer research
A recent study published in Neuro-Oncology has identified novel genomic associations with brain metastasis and progression in colorectal cancer, offering a potential basis for personalized clinical management. Researchers at Memorial Sloan-Kettering Cancer Center analyzed next-generation sequencing data from patients with colorectal cancer to identify genomic features associated with brain metastasis
Cancer research
Investigators at the University of Paris have published new research on the effectiveness of anti-EGFR rechallenge therapy in metastatic colorectal cancer. The study, titled "Circulating Tumor Dna Driving Anti-egfr Rechallenge Therapy In Metastatic Colorectal Cancer: the Rasintro Prospective Multicenter Study," suggests that patients with RAS/BRAF wild-type metastatic
Colorectal cancer
Researchers from Zanjan University of Medical Sciences have made significant strides in the field of personalized medicine, particularly in the diagnosis, staging, and treatment of colorectal cancer (CRC). A recent study published in Abdominal Radiology found that radiomics-based artificial intelligence (AI) models can improve the accuracy of CRC diagnosis and
Cancer research
Researchers from the IRCCS Foundation National Cancer Institute in Milan, Italy, have published a study in The Oncologist, a leading oncology journal, highlighting the superiority of dual PD-1/CTLA-4 blockade with nivolumab and ipilimumab in treating metastatic colorectal cancer (mCRC) patients with deficient mismatch repair (dMMR) and/or microsatellite instability-high
Cancer research
Research from Sichuan University published in the Cochrane Database of Systematic Reviews in 2025 has yielded new data on the effects of intraperitoneal chemotherapy (IPC) in gastric cancer patients, with mixed results on survival rates, quality of life, and adverse events. The study, which included nine parallel randomized controlled trials
Cancer metastasis
New research conducted at the Department of Nuclear Medicine, Balikesir Ataturk City Hospital in Turkiye has shed light on the prognostic factors for metastatic castration-resistant prostate cancer (mCRPC) patients undergoing 177Lu-PSMA-617 radioligand therapy. The study retrospectively examined 31 patients with median age 69 (57-80) years, who received treatment between 2021
Cancer metastasis
Research at University College London's Division of Surgery and Interventional Sciences has analyzed the real-world data of patients with metastatic hormone-sensitive prostate cancer (mHSPC) to estimate the risks of cardiovascular adverse events (AEs). The study, published in European Urology Focus, utilized the PIONEER Big Data platform to define
Cancer research
Focal leptomeningeal extension, a newly identified entity, has been found to display patterns of intracranial failure similar to parenchymal brain metastases. Researchers at the Dana-Farber Cancer Institute conducted a study to assess whether patients with focal leptomeningeal extension can be managed with stereotactic radiation without excess development of marginal recurrences
Cancer research
A new study published in the European Journal of Cancer has investigated sex-specific survival differences in metastatic melanoma patients who received first-line therapy. The prospective multicenter DeCOG skin cancer registry ADOREG included 2032 patients, with 1274 males (62.7%) and 758 females (37.3%), who received immune checkpoint inhibition (ICI)
Cancer research
Recent research published in Open Life Sciences investigates the combination of immunotherapy and whole-brain radiotherapy in treating patients with multiple brain metastases. Investigators from the Affiliated Cancer Hospital of Nanjing Medical University conducted a retrospective cohort study involving 57 patients diagnosed with brain metastases between 2021 and 2023. The study
Cancer research
Current study results on solid cancer have been published, detailing the efficacy of ulevostinag, a cyclic dinucleotide stimulator of IFN genes (STING) agonist, in combination with pembrolizumab in treating advanced or metastatic solid tumors or lymphomas. The research, conducted by the Institute for Cancer Research, involved two clinical trials: a
