Cancer research
Recent research has shed light on the increased risk of ischemic stroke in cancer patients who develop venous thromboembolism (VTE). A study published in Blood Advances observed that patients treated with direct oral anticoagulants (DOACs) had a higher cumulative incidence of ischemic stroke compared to those treated with low-molecular-weight heparin
Cancer research
Researchers from Ohio University have conducted a study to explore the impact of growth hormone (GH) signaling on therapy resistance and disease progression in bladder cancer. The study, published in the International Journal of Molecular Sciences, revealed that high tumoral expression of GH was associated with differential upregulation of genes
Cancer research
Researchers from Guangdong Medical University have developed a prognostic signature consisting of fatty acid metabolism genes using machine learning algorithms to predict biochemical recurrence and aid in androgen receptor signaling inhibitors (ARSI) therapy in prostate cancer patients. The study's findings suggest that the FAM-related gene score (FAMRGs) can
Cancer research
Researchers at Jiangsu University have explored the effectiveness of combining phototherapy with chemotherapy as a treatment strategy for cancer. According to their study, this approach, known as Phototherapy Integrated Chemotherapy (PIC), has shown promising results in eliminating cancer cells while minimizing toxic side effects. The study, supported by the National
Cancer research
Researchers at the Medical University of Sofia have conducted a multicenter, retrospective study to evaluate the predictive value of mutations in effector genes versus sensor genes in patients with metastatic castration-resistant prostate cancer (mCRPC) classified as homologous recombination deficiency (HRD)-positive. The study found that patients with effector mutations in
Cancer research
Researchers at the University of Nebraska Medical Center have made a significant discovery in the field of oncology, unveiling a novel androgen receptor target gene called ECD that plays a pivotal role in promoting prostate cancer tumorigenesis by regulating glycolysis. The study, published in the journal Oncogene, highlights the critical
Cancer research
A new study on the treatment of metastatic hormone-sensitive prostate cancer (mHSPC) has highlighted the evolving landscape of clinical trial evidence and real-world practice. The researchers, from Bayer HealthCare, conducted a retrospective study using administrative claims data in the Komodo Research Dataset from January 2016 to September 2023. The study
Cancer research
Organ transplant recipients in the United States have a lower risk of developing breast and prostate cancers compared to the general population. To explore this observation, researchers conducted a case-control study using the SEER-Medicare database, examining US adults aged 65 years or older. The study found that solid organ transplant
Cancer research
A clinical trial led by Peter Schwartz, MD, PhD, at the Indiana University School of Medicine found that providing patients and their healthcare providers with personalized colorectal cancer risk information did not increase screening rates for this deadly disease. The study, published in the Annals of Internal Medicine, involved 214
Cancer research
Research conducted by the Sakai City Medical Center has provided new insights into the effectiveness of radiotherapy (RT) and transarterial embolization (TAE) in treating advanced gastric cancer bleeding. The study, published in the journal BMC Gastroenterology, analyzed patients with advanced gastric cancer who experienced uncontrollable bleeding and were treated with
Cancer research
National Cancer Institute (NCI) has announced an interventional clinical trial to assess the feasibility of a survivin peptide vaccine, called SurVaxM, as an interception agent in patients at high risk for lung cancer. The trial's principal investigator is Saikrishna S Yendamuri, and it aims to enroll 80 participants
Cancer research
Researchers at the University of Oxford's Nuffield Department of Primary Care Health Sciences have conducted a major UK study to analyze a cancer diagnosis pathway for patients presenting with non-specific symptoms (NSS), such as unexplained weight loss or fatigue. The study, published in the Lancet Primary Care, tracked
